# Diffuse2Seg: Diffusion Models Can Segment Anything Without Supervision

arXiv: https://arxiv.org/abs/2609.06491 · HTML: https://mlsanity.com/paper/2609.06491/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 56 of its 60 references that are in the map.
- First posted on arXiv 6 Sep 2026.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 30 of 56)

- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Microsoft COCO: Common Objects in Context](https://mlsanity.com/paper/1405.0312/) (2014)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [DINOv2: Learning Robust Visual Features without Supervision](https://mlsanity.com/paper/2304.07193/) (2023)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [SDXL: Improving Latent Diffusion Models for High-Resolution Image Synthesis](https://mlsanity.com/paper/2307.01952/) (2023)
- [Scaling Rectified Flow Transformers for High-Resolution Image Synthesis](https://mlsanity.com/paper/2403.03206/) (2024)
- [Unsupervised Learning of Visual Features by Contrasting Cluster Assignments](https://mlsanity.com/paper/2006.09882/) (2020)
- [BEiT: BERT Pre-Training of Image Transformers](https://mlsanity.com/paper/2106.08254/) (2021)
- [Masked-attention Mask Transformer for Universal Image Segmentation](https://mlsanity.com/paper/2112.01527/) (2021)
- [An Empirical Study of Training Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.02057/) (2021)
- [Simple Copy-Paste is a Strong Data Augmentation Method for Instance Segmentation](https://mlsanity.com/paper/2012.07177/) (2020)
- [Emergent Correspondence from Image Diffusion](https://mlsanity.com/paper/2306.03881/) (2023)
- [EVA-02: A Visual Representation for Neon Genesis](https://mlsanity.com/paper/2303.11331/) (2023)
- [Localizing Objects with Self-Supervised Transformers and no Labels](https://mlsanity.com/paper/2109.14279/) (2021)
- [Diffusion Hyperfeatures: Searching Through Time and Space for Semantic Correspondence](https://mlsanity.com/paper/2305.14334/) (2023)
- [Cut and Learn for Unsupervised Object Detection and Instance Segmentation](https://mlsanity.com/paper/2301.11320/) (2023)
- [Self-Supervised Transformers for Unsupervised Object Discovery using Normalized Cut](https://mlsanity.com/paper/2202.11539/) (2022)
- [PACO: Parts and Attributes of Common Objects](https://mlsanity.com/paper/2301.01795/) (2023)
- [Unidentified Video Objects: A Benchmark for Dense, Open-World Segmentation](https://mlsanity.com/paper/2104.04691/) (2021)
- [Diffuse, Attend, and Segment: Unsupervised Zero-Shot Segmentation using Stable Diffusion](https://mlsanity.com/paper/2308.12469/) (2023)
- [CascadePSP: Toward Class-Agnostic and Very High-Resolution Segmentation via Global and Local Refinement](https://mlsanity.com/paper/2005.02551/) (2020)
- [High-Quality Entity Segmentation](https://mlsanity.com/paper/2211.05776/) (2022)
- [Open-World Entity Segmentation](https://mlsanity.com/paper/2107.14228/) (2021)
- [Unsupervised Object Localization: Observing the Background to Discover Objects](https://mlsanity.com/paper/2212.07834/) (2022)
- [Your ViT is Secretly an Image Segmentation Model](https://mlsanity.com/paper/2503.19108/) (2025)
- [ConceptAttention: Diffusion Transformers Learn Highly Interpretable Features](https://mlsanity.com/paper/2502.04320/) (2025)

## Abstract (arXiv)

Open-world entity segmentation aims to predict masks for arbitrary objects across domains and at multiple granularities, from parts to whole objects. In this setting, SAM sets a strong standard: trained on SA-1B, comprising 11M images and over 1B carefully annotated masks, it achieves remarkable zero-shot performance. Collecting such labels is expensive and time-consuming, however, which limits how far this recipe can scale. Text-to-image diffusion models offer a way around this. Their intermediate features transfer well across perception tasks, and since object structure emerges as the model denoises a noise sample into an image conditioned on a text prompt, that structure is already encoded in these representations. They can therefore be exploited for open-world entity segmentation without retraining or supervision. Building on this observation, we introduce Diffuse2Seg, which repurposes generative diffusion models for automatic mask generation by propagating a grid of point prompts through their self-attention representations in an edge-preserving manner. Diffuse2Seg produces multi-granular instance masks and outperforms prior state-of-the-art label generators by 4.3-7.1 p.p. in AR_1000 across five domains. Training an instance segmentation model on these generated masks advances detector-free open-world segmentation by 7.4 and 7.7 p.p. on "things" and "stuff+things" datasets and surpasses the detector-based UnSAM on "stuff+things" by 2.1 p.p. in AR_1000. Finally, we show that a model trained on Diffuse2Seg labels provides a strong initialization for semi-supervised learning, outperforming its fully supervised counterpart with already 5k labeled images.