# AutoKD: Autonomous Knowledge Discovery

arXiv: https://arxiv.org/abs/2609.06366 · HTML: https://mlsanity.com/paper/2609.06366/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 9 of its 35 references that are in the map.
- First posted on arXiv 6 Sep 2026.

## Builds on (most cited first, 9 of 9)

- [Sentence-BERT: Sentence Embeddings using Siamese BERT-Networks](https://mlsanity.com/paper/1908.10084/) (2019)
- [Evaluating Large Language Models Trained on Code](https://mlsanity.com/paper/2107.03374/) (2021)
- [Agent Laboratory: Using LLM Agents as Research Assistants](https://mlsanity.com/paper/2501.04227/) (2025)
- [AutoML: A Survey of the State-of-the-Art](https://mlsanity.com/paper/1908.00709/) (2019)
- [Can LLMs Generate Novel Research Ideas? A Large-Scale Human Study with 100+ NLP Researchers](https://mlsanity.com/paper/2409.04109/) (2024)
- [Data Interpreter: An LLM Agent For Data Science](https://mlsanity.com/paper/2402.18679/) (2024)
- [PaperQA: Retrieval-Augmented Generative Agent for Scientific Research](https://mlsanity.com/paper/2312.07559/) (2023)
- [Let Your Graph Do the Talking: Encoding Structured Data for LLMs](https://mlsanity.com/paper/2402.05862/) (2024)
- [Kosmos: An AI Scientist for Autonomous Discovery](https://mlsanity.com/paper/2511.02824/) (2025)

## Abstract (arXiv)

Scientific discovery in data-rich domains is currently constrained by human bandwidth: the growth in the volume and complexity of real-world data far outpaces the rate at which researchers can read, reason, and synthesize. Recent LLM-based multi-agent systems have begun to automate portions of the research cycle, but they target hypothesis generation in settings where validation cannot itself be automated, and each run is one-shot, with no mechanism for findings to accumulate or steer subsequent inquiry. This paper introduces AutoKD, a multi-agent framework for autonomous knowledge discovery that is both computational and cumulative, allowing validated findings to persist and inform subsequent inquiry. Six coordinated LLM agents collaborate in an open-ended discovery loop, where accepted findings are stored in a persistent insight graph that serves as both long-term memory and an exploration-steering mechanism. We evaluate AutoKD on three diverse datasets from two perspectives: Open-ended Quality against published findings, and Conditioned Quality via literature-derived queries. Across both evaluation perspectives, AutoKD covers known findings and surfaces substantive discoveries that complement human-driven research. Our code is available at https://github.com/GeQinwen/AutoKD.