# Computationally Efficient Pathology Segmentation using Knowledge Distillation from Foundation Models

arXiv: https://arxiv.org/abs/2609.03947 · HTML: https://mlsanity.com/paper/2609.03947/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Distillation for medical imaging, one of 12 directions in Knowledge distillation.
- First posted on arXiv 3 Sep 2026.

## Placed in

- Knowledge distillation / [Distillation for medical imaging](https://mlsanity.com/distill/distillation-for-medical-imaging/)

## Abstract (arXiv)

Automatic tissue segmentation is essential for large-scale analysis of histopathology whole-slide images (WSIs), but accurate pixel-level segmentation remains challenging. Pixel-level annotations are expensive to obtain, models pre-trained on natural images may transfer poorly to histopathology, and pathology foundation models, despite their strong representations, are computationally expensive to deploy at scale. We address these challenges with a foundation-model knowledge distillation framework for efficient tissue segmentation. We first train Virchow2-based segmentation teachers, including a LoRA-adapted variant, achieving state-of-the-art or highly competitive performance across four datasets: PUMA, IGNITE, BEETLE, and a private blood vessel segmentation dataset. We then transfer response-level and feature-level knowledge from these teachers into compact student networks. Distillation consistently improves student performance over supervised training alone, producing state-of-the-art or near state-of-the-art results with substantially fewer parameters and up to ten-fold higher inference throughput than foundation-model-based segmentation networks. These results show that foundation-model knowledge can be effectively transferred to efficient segmentation models for scalable deployment without compromising performance. Models trained on the public datasets will be released through TIAToolbox.