# Distilled Rapid Embedding Transfer (DRET): Parameter-Efficient Biomedical Domain Adaptation via Priority-Based Embedding Transfer

arXiv: https://arxiv.org/abs/2609.02898 · HTML: https://mlsanity.com/paper/2609.02898/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 8 of its 19 references that are in the map.
- First posted on arXiv 4 Jul 2026.

## Builds on (most cited first, 8 of 8)

- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [DistilBERT, a distilled version of BERT: smaller, faster, cheaper and lighter](https://mlsanity.com/paper/1910.01108/) (2019)
- [BioBERT: a pre-trained biomedical language representation model for biomedical text mining](https://mlsanity.com/paper/1901.08746/) (2019)
- [SciBERT: A Pretrained Language Model for Scientific Text](https://mlsanity.com/paper/1903.10676/) (2019)
- [Publicly Available Clinical BERT Embeddings](https://mlsanity.com/paper/1904.03323/) (2019)
- [LinkBERT: Pretraining Language Models with Document Links](https://mlsanity.com/paper/2203.15827/) (2022)
- [A Corpus with Multi-Level Annotations of Patients, Interventions and Outcomes to Support Language Processing for Medical Literature](https://mlsanity.com/paper/1806.04185/) (2018)
- [Automating Systematic Literature Reviews with Natural Language Processing and Text Mining: a Systematic Literature Review](https://mlsanity.com/paper/2211.15397/) (2022)

## Abstract (arXiv)

Large domain-specific language models such as BioBERT and ClinicalBERT achieve strong performance on biomedical NLP tasks, but their computational demands make them impractical for many real-world deployments. General-purpose, parameter-efficient models such as DistilBERT are lightweight yet lack the domain knowledge required for specialized tasks such as PICO (Population, Intervention, Comparison, Outcome) classification. We introduce Distilled Rapid Embedding Transfer (DRET), a knowledge-transfer paradigm that injects biomedical domain knowledge from large specialized models into a smaller general-purpose model without retraining on the original specialized corpora. DRET is developed as an iterative family of strategies: a unified tokenizer-merge strategy (DRET 1.x), hybrid embedding averaging (DRET 2.0), and a priority-based embedding-transfer mechanism (DRET 3.x) that hierarchically selects embeddings from the most authoritative source models, further combined with embedding-layer freezing, differential learning rates, label propagation, and imbalance-aware loss functions (DRET 4.x). We evaluate DRET on token-level PICO classification using the EBM-NLP corpus under severe class imbalance, across a twelve-metric battery. DRET-enhanced DistilBERT (66M parameters) attains balanced accuracy, recall, and ROC-AUC competitive with, and on several class-wise metrics exceeding, models an order of magnitude larger, while retaining DistilBERT's efficiency. We further show that transfer occurs at the embedding level through cosine-similarity, semantic-shift, and t-SNE analyses. DRET offers a scalable, resource-efficient route to near-domain-expert performance for biomedical text mining, with direct application to automated systematic literature reviews and clinical decision support.