# Physics-Driven Independent Pair Generation for Iterative Self-Supervised Low-Dose CT Denoising

arXiv: https://arxiv.org/abs/2609.02654 · HTML: https://mlsanity.com/paper/2609.02654/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 12 of its 38 references that are in the map.
- First posted on arXiv 1 Sep 2026.

## Builds on (most cited first, 12 of 12)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Noise2Noise: Learning Image Restoration without Clean Data](https://mlsanity.com/paper/1803.04189/) (2018)
- [Noise2Void - Learning Denoising from Single Noisy Images](https://mlsanity.com/paper/1811.10980/) (2018)
- [Noise2Self: Blind Denoising by Self-Supervision](https://mlsanity.com/paper/1901.11365/) (2019)
- [Neighbor2Neighbor: Self-Supervised Denoising from Single Noisy Images](https://mlsanity.com/paper/2101.02824/) (2021)
- [Blind2Unblind: Self-Supervised Image Denoising with Visible Blind Spots](https://mlsanity.com/paper/2203.06967/) (2022)
- [CoreDiff: Contextual Error-Modulated Generalized Diffusion Model for Low-Dose CT Denoising and Generalization](https://mlsanity.com/paper/2304.01814/) (2023)
- [Exploring Efficient Asymmetric Blind-Spots for Self-Supervised Denoising in Real-World Scenarios](https://mlsanity.com/paper/2303.16783/) (2023)
- [Data thinning for convolution-closed distributions](https://mlsanity.com/paper/2301.07276/) (2023)
- [WIA-LD2ND: Wavelet-based Image Alignment for Self-supervised Low-Dose CT Denoising](https://mlsanity.com/paper/2403.11672/) (2024)
- [Positive2Negative: Breaking the Information-Lossy Barrier in Self-Supervised Single Image Denoising](https://mlsanity.com/paper/2412.16460/) (2024)
- [PFCM: Poisson flow consistency models for low-dose CT image denoising](https://mlsanity.com/paper/2402.08159/) (2024)

## Abstract (arXiv)

Low-dose computed tomography (LDCT) measurements contain mixed Poisson-Gaussian noise. However, most self-supervised methods rely on generic image statistics and do not explicitly model this noise, which may limit their ability to effectively suppress realistic LDCT noise. To address this issue, we propose a physics-driven framework with cross-domain iteration for self-supervised LDCT denoising. The proposed framework proceeds in three main steps. First, a learned sinogram prior and the LDCT noise model guide posterior inference of photon counts, enabling separation of the Poisson and Gaussian components. Second, the separated Poisson and Gaussian components are respectively processed by binomial thinning and Gaussian data thinning to construct two branches, and residual scaling matches each branch's noise level to that of the observation, yielding a training pair with approximately independent noise realizations from one low-dose measurement. Finally, the pair is used to train an image-domain network whose forward-projected outputs update the prior. Through cross-domain iteration, the prior and the training pair are progressively refined while maintaining consistency with CT acquisition physics. Experiments on simulated data from AAPM, LIDC-IDRI, and LoDoPaB-CT and on real LDCT data show consistent gains over the evaluated self-supervised baselines across dose levels, with performance comparable to the evaluated supervised baseline.