# Robust Neural Stimulation Response Modeling Through Meta-Learning and Pretraining

arXiv: https://arxiv.org/abs/2608.26649 · HTML: https://mlsanity.com/paper/2608.26649/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 2 of its 28 references that are in the map.
- First posted on arXiv 27 Aug 2026.

## Builds on (most cited first, 2 of 2)

- [Model-Agnostic Meta-Learning for EEG Motor Imagery Decoding in Brain-Computer-Interfacing](https://mlsanity.com/paper/2103.08664/) (2021)
- [Neural Co-Processors for Restoring Brain Function: Results from a Cortical Model of Grasping](https://mlsanity.com/paper/2210.11478/) (2022)

## Abstract (arXiv)

Objective: Model-based closed-loop neural stimulation holds promise for therapeutic applications ranging from Parkinson's disease to sensory restoration, but deployment has been limited by two obstacles: 1) forecasting models for predicting the consequences of stimulation fail catastrophically on a meaningful fraction of sessions, and 2) per-session calibration requirements are often incompatible with clinical constraints. We address both by demonstrating, for the first time, that meta-learning and pretraining can be applied to neural stimulation response modeling. Methods: Temporal basis function models (TBFMs) forecast state-dependent neural responses to stimulation. We extend TBFMs with cross-session pretraining using a novel architecture and algorithm based on model-agnostic meta-learning (MAML), evaluating them on 40 sessions of optogenetic stimulation in primary sensorimotor cortex of two non-human primates. Results: Meta-learning substantially reduces catastrophic forecast failure: for a 1k calibration set size, sessions with test R-squared < 0.05 drop from 16 of 40 (single-session training) to 1 (MAML-pretrained), and prediction intervals become significantly narrower (p < 0.05). Calibration requirements are reduced by 50-90% at matched accuracy, enabling experiments otherwise infeasible within clinical session-time constraints. Conclusion: Our results demonstrate that cross-session structure in stimulation responses is consistent enough to support pretraining, providing the first empirical evidence that meta-learning approaches are viable for neural stimulation. Significance: The robustness and sample efficiency gains directly address known obstacles to deploying model-based stimulation controllers. Our results motivate community efforts to assemble standardized multi-site stimulation datasets and to further explore meta-learning for robust closed-loop stimulation.