# SciMIF: Understanding Multimodal Instruction Following in Scientific Domains

arXiv: https://arxiv.org/abs/2608.25973 · HTML: https://mlsanity.com/paper/2608.25973/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in MLLM training and visual instruction tuning, one of 16 directions in Multimodal LLMs / vision-language models.
- Builds on 16 of its 25 references that are in the map.
- First posted on arXiv 26 Aug 2026.

## Placed in

- Multimodal LLMs / vision-language models / [MLLM training and visual instruction tuning](https://mlsanity.com/mllm/mllm-training-and-visual-instruction-tuning/)

## Builds on (most cited first, 16 of 16)

- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [Self-Instruct: Aligning Language Models with Self-Generated Instructions](https://mlsanity.com/paper/2212.10560/) (2022)
- [MMMU: A Massive Multi-discipline Multimodal Understanding and Reasoning Benchmark for Expert AGI](https://mlsanity.com/paper/2311.16502/) (2023)
- [MathVista: Evaluating Mathematical Reasoning of Foundation Models in Visual Contexts](https://mlsanity.com/paper/2310.02255/) (2023)
- [InternVL3.5: Advancing Open-Source Multimodal Models in Versatility, Reasoning, and Efficiency](https://mlsanity.com/paper/2508.18265/) (2025)
- [GeoQA: A Geometric Question Answering Benchmark Towards Multimodal Numerical Reasoning](https://mlsanity.com/paper/2105.14517/) (2021)
- [LAB-Bench: Measuring Capabilities of Language Models for Biology Research](https://mlsanity.com/paper/2407.10362/) (2024)
- [PhysReason: A Comprehensive Benchmark towards Physics-Based Reasoning](https://mlsanity.com/paper/2502.12054/) (2025)
- [MM-IFEngine: Towards Multimodal Instruction Following](https://mlsanity.com/paper/2504.07957/) (2025)
- [CompassVerifier: A Unified and Robust Verifier for LLMs Evaluation and Outcome Reward](https://mlsanity.com/paper/2508.03686/) (2025)
- [Speak-to-Structure: Evaluating LLMs in Open-domain Natural Language-Driven Molecule Generation](https://mlsanity.com/paper/2412.14642/) (2024)
- [LLM4Mat-Bench: Benchmarking Large Language Models for Materials Property Prediction](https://mlsanity.com/paper/2411.00177/) (2024)
- [MatSciBench: Benchmarking the Reasoning Ability of Large Language Models in Materials Science](https://mlsanity.com/paper/2510.12171/) (2025)
- [Can Multimodal LLMs See Materials Clearly? A Multimodal Benchmark on Materials Characterization](https://mlsanity.com/paper/2509.09307/) (2025)
- [EarthSE: A Benchmark for Evaluating Earth Scientific Exploration Capability of LLMs](https://mlsanity.com/paper/2505.17139/) (2025)
- [SciIF: Benchmarking Scientific Instruction Following Towards Rigorous Scientific Intelligence](https://mlsanity.com/paper/2601.04770/) (2026)

## Abstract (arXiv)

Understanding instruction-following capabilities in scientific domains is essential for effectively leveraging Multimodal Large Language Models (MLLMs) to advance the development of scientific fields. In this work, we introduce SciMIF, a novel benchmark designed to evaluate the capability of MLLMs in following complex scientific instructions. Specifically, based on an extensive analysis of 22 distinct tasks across 5 representative scientific disciplines, we propose a comprehensive taxonomy comprising 10 constraint groups that captures both general functional requirements and discipline-specific characteristics. Guided by this taxonomy, we develop a high-fidelity instruction injection pipeline to systematically augment existing scientific datasets. We conduct comprehensive experiments on multiple state-of-the-art closed-source and open-source MLLMs. Our findings reveal significant performance disparities across different scientific disciplines, with chemistry posing greater challenges for current MLLMs. Furthermore, we observe that increasing the model scale does not yield corresponding improvements in constraint adherence, and current models still struggle severely with fine-grained constraints and instructions requiring the deep application of disciplinary knowledge. SciMIF fills the current void in evaluating multimodal instruction adherence within scientific domains, laying a crucial foundation for future enhancements of MLLMs in rigorous scientific applications. Data and code will be released at https://github.com/shenye7436/SciMIF .