# ReMAP: Self-supervised learning to unveil brain representations and vulnerability

arXiv: https://arxiv.org/abs/2608.22042 · HTML: https://mlsanity.com/paper/2608.22042/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 10 of its 51 references that are in the map.
- First posted on arXiv 22 Aug 2026.

## Builds on (most cited first, 10 of 10)

- [UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction](https://mlsanity.com/paper/1802.03426/) (2018)
- [BENDR: using transformers and a contrastive self-supervised learning task to learn from massive amounts of EEG data](https://mlsanity.com/paper/2101.12037/) (2021)
- [CBraMod: A Criss-Cross Brain Foundation Model for EEG Decoding](https://mlsanity.com/paper/2412.07236/) (2024)
- [REVE: A Foundation Model for EEG -- Adapting to Any Setup with Large-Scale Pretraining on 25,000 Subjects](https://mlsanity.com/paper/2510.21585/) (2025)
- [3KG: Contrastive Learning of 12-Lead Electrocardiograms using Physiologically-Inspired Augmentations](https://mlsanity.com/paper/2106.04452/) (2021)
- [LUNA: Efficient and Topology-Agnostic Foundation Model for EEG Signal Analysis](https://mlsanity.com/paper/2510.22257/) (2025)
- [S-JEPA: towards seamless cross-dataset transfer through dynamic spatial attention](https://mlsanity.com/paper/2403.11772/) (2024)
- [NeuralBench: A Unifying Framework to Benchmark NeuroAI Models](https://mlsanity.com/paper/2605.08495/) (2026)
- [EEG-Bench: A Benchmark for EEG Foundation Models in Clinical Applications](https://mlsanity.com/paper/2512.08959/) (2025)
- [Channel Adaptation for EEG Foundation Models: A Systematic Benchmark Across Architectures, Tasks, and Training Regimes](https://mlsanity.com/paper/2604.23091/) (2026)

## Abstract (arXiv)

General anesthesia offers a rare opportunity to observe the human brain under a standardized, controlled perturbation. Yet intraoperative electroencephalography (EEG) is almost always reduced to a single proprietary depth index, collapsing a rich trajectory into one number and discarding how a brain moves between states. Here we ask whether the geometry of that trajectory, not merely the depth it reaches, carries clinically meaningful information. Using similarity-based self-supervised learning on raw, two-electrode frontal EEG, with no labels, we place each recording within a low-dimensional space in which anesthetic depth becomes one readable axis while the shape of a patient's path encodes additional structure. We validate the representation across two cohorts and two acquisition systems totaling more than 1,000 patients. Depth of anesthesia is predicted accurately (BIS mean absolute error = 3.2, R2 = 0.82), and in the sparse-montage setting our compact ( 68k parameter) model remains competitive with EEG foundation models orders of magnitude larger (4M-157M parameters), indicating that matching the representation to the recording dominates raw scale. The learned space organizes age along its own gradient, independent from depth, without supervision. The same space also aligns with interpretable anesthetic signatures like frontal alpha, slow-delta, and burst suppression, linking this data-driven representation to established neurophysiology. On an independent cohort with longitudinal follow-up, the geometry of the early trajectory separates 30- month cognitive and mortality outcomes complementary to age (AUROC 0.86). These results suggest that the path a brain traces through anesthesia is a label-efficient correlate of latent vulnerability, motivating prospective validation.