# Towards Investigating Residual Hearing Loss: Quantification of Fibrosis in a Novel Cochlear OCT Dataset

arXiv: https://arxiv.org/abs/2608.21189 · HTML: https://mlsanity.com/paper/2608.21189/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 22 of its 55 references that are in the map.
- First posted on arXiv 21 Aug 2026.

## Builds on (most cited first, 22 of 22)

- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [ImageNet Large Scale Visual Recognition Challenge](https://mlsanity.com/paper/1409.0575/) (2014)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [EfficientNet: Rethinking Model Scaling for Convolutional Neural Networks](https://mlsanity.com/paper/1905.11946/) (2019)
- [Squeeze-and-Excitation Networks](https://mlsanity.com/paper/1709.01507/) (2017)
- [Encoder-Decoder with Atrous Separable Convolution for Semantic Image Segmentation](https://mlsanity.com/paper/1802.02611/) (2018)
- [SegFormer: Simple and Efficient Design for Semantic Segmentation with Transformers](https://mlsanity.com/paper/2105.15203/) (2021)
- [Group Normalization](https://mlsanity.com/paper/1803.08494/) (2018)
- [UNETR: Transformers for 3D Medical Image Segmentation](https://mlsanity.com/paper/2103.10504/) (2021)
- [Generalised Dice overlap as a deep learning loss function for highly unbalanced segmentations](https://mlsanity.com/paper/1707.03237/) (2017)
- [Deep learning with noisy labels: exploring techniques and remedies in medical image analysis](https://mlsanity.com/paper/1912.02911/) (2019)
- [Unified Focal loss: Generalising Dice and cross entropy-based losses to handle class imbalanced medical image segmentation](https://mlsanity.com/paper/2102.04525/) (2021)
- [Towards a Guideline for Evaluation Metrics in Medical Image Segmentation](https://mlsanity.com/paper/2202.05273/) (2022)
- [Understanding Imbalanced Semantic Segmentation Through Neural Collapse](https://mlsanity.com/paper/2301.01100/) (2023)
- [How to build the best medical image segmentation algorithm using foundation models: a comprehensive empirical study with Segment Anything Model](https://mlsanity.com/paper/2404.09957/) (2024)
- [A Survey on Activation Functions and their relation with Xavier and He Normal Initialization](https://mlsanity.com/paper/2004.06632/) (2020)
- [Do We Really Need Dice? The Hidden Region-Size Biases of Segmentation Losses](https://mlsanity.com/paper/2104.08717/) (2021)
- [Narrowing the semantic gaps in U-Net with learnable skip connections: The case of medical image segmentation](https://mlsanity.com/paper/2312.15182/) (2023)
- [Spatial-Frequency U-Net for Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2307.14648/) (2023)
- [A Computational Model of the Electrically or Acoustically Evoked Compound Action Potential in Cochlear Implant Users with Residual Hearing](https://mlsanity.com/paper/2402.07673/) (2024)

## Abstract (arXiv)

Objective: Cochlear implants (CIs) are bionic prostheses that restores hearing via electrical stimulation of the auditory nerve. Hybrid CIs, which use electroacoustic stimulation (EAS), combine residual low-frequency acoustic hearing with CI electrical stimulation. Intracochlear fibrosis, which forms in response to the presence of the implant, may impede residual hearing function and gradually reduce the efficacy of EAS. It is therefore a translational objective to study the formation of cochlear fibrosis in rodents, with the goal of reducing fibrotic burden and improving outcomes for CI patients. Methods: We generate and annotate a novel dataset of optical coherence tomography (OCT) images from chronically implanted guinea pigs as part of an ongoing study focused on implant induced fibrosis. Objectively assessing fibrotic burden in this model, with high resolution and repeatability, presents an obvious use case for computer vision methods. Results: We present the results of several state-of-the-art semantic segmentation models and compare their efficacy for identifying cochlear fibrosis and other relevant annotations, using a new library of manually segmented OCT images. Conclusions: We find that the best performance is achieved by using a modified version of the well-known UNET architecture (which we term 2D-OCT-UNET) that operates on the upscaled OCT input resolution. Significance: For the first time, we have successfully applied computer vision techniques to an OCT dataset of implanted cochleae with fibrosis. Using this deep learning model, the cochlear fibrotic burden calculation can be reliably carried out as we verify in our experimental section. The dataset and the project code are available at: https://github.com/juliadietlmeier/CF-OCT-segmentation