# Foundation Agents Meet Agentic Deep Research: Evidence-Grounded Clinical Code Forecasting

arXiv: https://arxiv.org/abs/2608.17075 · HTML: https://mlsanity.com/paper/2608.17075/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical and scientific domain agents, one of 16 directions in LLM agents and tool use.
- Builds on 7 of its 44 references that are in the map.
- First posted on arXiv 17 Aug 2026.

## Placed in

- LLM agents and tool use / [Medical and scientific domain agents](https://mlsanity.com/agents/medical-and-scientific-domain-agents/)

## Builds on (most cited first, 7 of 7)

- [Search-R1: Training LLMs to Reason and Leverage Search Engines with Reinforcement Learning](https://mlsanity.com/paper/2503.09516/) (2025)
- [R1-Searcher: Incentivizing the Search Capability in LLMs via Reinforcement Learning](https://mlsanity.com/paper/2503.05592/) (2025)
- [BioMedLM: A 2.7B Parameter Language Model Trained On Biomedical Text](https://mlsanity.com/paper/2403.18421/) (2024)
- [Deep Research: A Systematic Survey](https://mlsanity.com/paper/2512.02038/) (2025)
- [RAG-R1: Incentivizing the Search and Reasoning Capabilities of LLMs through Multi-query Parallelism](https://mlsanity.com/paper/2507.02962/) (2025)
- [Overcoming Uncertain Incompleteness for Robust Multimodal Sequential Diagnosis Prediction via Curriculum Data Erasing Guided Knowledge Distillation](https://mlsanity.com/paper/2407.19540/) (2024)
- [Scaling Recurrence-aware Foundation Models for Clinical Records via Next-Visit Prediction](https://mlsanity.com/paper/2603.24562/) (2026)

## Abstract (arXiv)

Next-encounter ICD forecasting predicts which standardized diagnosis codes will be documented at a future visit from the longitudinal record available beforehand. The task is prospective and multi-label: the target note does not yet exist, and several codes may be correct. Structured EHR foundation models capture recurrence and temporal progression, whereas language foundation models generate flexible diagnostic hypotheses. We introduce ICD-Deepresearch, a DeepResearch workflow that composes these predictive foundation models with medical search and ICD dictionaries. Because no source reveals the future code set, research evaluates candidate transitions by linking patient evidence, external clinical relations, and exact code semantics under a fixed top-K budget. Candidate Generation uses SparseEHR to produce an EHR Prior that initializes two bounded Research Expansion rounds; an independent GPT-5 Direct Forecast supplies complementary candidates. Final Selection validates, deduplicates, and jointly ranks both paths, after which a separate module writes rationales without changing predictions. Finally ICD-Deepresearch achieves patient-averaged precision/recall of 24.60/35.09% on MIMIC-III and 25.14/48.32% on MIMIC-IV. Physicians rate 51% and 68% of its retrieved documents useful, compared with 22% and 39% for standalone GPT-5 web search and 32% and 41% for Medical Deep Research. ICD-Deepresearch therefore improves over the registered local comparators while retrieving evidence with higher physician-rated usefulness than the standalone research systems