# CoM3eT: A foundation model for medical image analysis through federated, multidimensional context integration

arXiv: https://arxiv.org/abs/2608.16268 · HTML: https://mlsanity.com/paper/2608.16268/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 43 of its 90 references that are in the map.
- First posted on arXiv 17 Aug 2026.

## Builds on (most cited first, 30 of 43)

- [Microsoft COCO: Common Objects in Context](https://mlsanity.com/paper/1405.0312/) (2014)
- [Qwen3 Technical Report](https://mlsanity.com/paper/2505.09388/) (2025)
- [Communication-Efficient Learning of Deep Networks from Decentralized Data](https://mlsanity.com/paper/1602.05629/) (2016)
- [CheXpert: A Large Chest Radiograph Dataset with Uncertainty Labels and Expert Comparison](https://mlsanity.com/paper/1901.07031/) (2019)
- [ZeRO: Memory Optimizations Toward Training Trillion Parameter Models](https://mlsanity.com/paper/1910.02054/) (2019)
- [CoCa: Contrastive Captioners are Image-Text Foundation Models](https://mlsanity.com/paper/2205.01917/) (2022)
- [Swin Transformer V2: Scaling Up Capacity and Resolution](https://mlsanity.com/paper/2111.09883/) (2021)
- [Train Short, Test Long: Attention with Linear Biases Enables Input Length Extrapolation](https://mlsanity.com/paper/2108.12409/) (2021)
- [Video Swin Transformer](https://mlsanity.com/paper/2106.13230/) (2021)
- [The Medical Segmentation Decathlon](https://mlsanity.com/paper/2106.05735/) (2021)
- [ImageNet-21K Pretraining for the Masses](https://mlsanity.com/paper/2104.10972/) (2021)
- [TotalSegmentator: robust segmentation of 104 anatomical structures in CT images](https://mlsanity.com/paper/2208.05868/) (2022)
- [Kvasir-SEG: A Segmented Polyp Dataset](https://mlsanity.com/paper/1911.07069/) (2019)
- [Vision Transformer Adapter for Dense Predictions](https://mlsanity.com/paper/2205.08534/) (2022)
- [Flower: A Friendly Federated Learning Research Framework](https://mlsanity.com/paper/2007.14390/) (2020)
- [VinDr-CXR: An open dataset of chest X-rays with radiologist's annotations](https://mlsanity.com/paper/2012.15029/) (2020)
- [Multimodal Whole Slide Foundation Model for Pathology](https://mlsanity.com/paper/2411.19666/) (2024)
- [SONAR: Sentence-Level Multimodal and Language-Agnostic Representations](https://mlsanity.com/paper/2308.11466/) (2023)
- [MILD-Net: Minimal Information Loss Dilated Network for Gland Instance Segmentation in Colon Histology Images](https://mlsanity.com/paper/1806.01963/) (2018)
- [PRISM: A Multi-Modal Generative Foundation Model for Slide-Level Histopathology](https://mlsanity.com/paper/2405.10254/) (2024)
- [PathAsst: A Generative Foundation AI Assistant Towards Artificial General Intelligence of Pathology](https://mlsanity.com/paper/2305.15072/) (2023)
- [A Multimodal Vision Foundation Model for Clinical Dermatology](https://mlsanity.com/paper/2410.15038/) (2024)
- [BabyVision: Visual Reasoning Beyond Language](https://mlsanity.com/paper/2601.06521/) (2026)
- [Vision Foundation Models for Computed Tomography](https://mlsanity.com/paper/2501.09001/) (2025)
- [Overcoming Data Scarcity in Biomedical Imaging with a Foundational Multi-Task Model](https://mlsanity.com/paper/2311.09847/) (2023)
- [One Model is All You Need: Multi-Task Learning Enables Simultaneous Histology Image Segmentation and Classification](https://mlsanity.com/paper/2203.00077/) (2022)
- [CoNIC Challenge: Pushing the Frontiers of Nuclear Detection, Segmentation, Classification and Counting](https://mlsanity.com/paper/2303.06274/) (2023)
- [CheXmask: a large-scale dataset of anatomical segmentation masks for multi-center chest x-ray images](https://mlsanity.com/paper/2307.03293/) (2023)
- [Lumbar spine segmentation in MR images: a dataset and a public benchmark](https://mlsanity.com/paper/2306.12217/) (2023)
- [The ULS23 Challenge: a Baseline Model and Benchmark Dataset for 3D Universal Lesion Segmentation in Computed Tomography](https://mlsanity.com/paper/2406.05231/) (2024)

## Abstract (arXiv)

Medical foundation models improve generalization when training AI models with limited labeled data, but remain confined to a single specialty, such as pathology or radiology, and to either sparse or dense outputs, such as classification or segmentation. Here, we present CoM3eT (Co-representation Multidimensional Multitask Medical Transformer), a medical vision foundation model that unifies pathology and radiology, sparse and dense predictions, and two- and higher-dimensional inputs by modeling multidimensional context with attention. CoM3eT outperformed other medical foundation models in an open competition spanning five tomographic, four whole-specimen, and three two-dimensional datasets, covering sparse and dense prediction tasks as well as report generation. When adapted across diverse clinical applications, training fewer than 2.5% of parameters achieved performance comparable to full fine-tuning, enabling research without access to high-performance GPU clusters. Applied to federated learning across hospitals, this approach achieved performance comparable to pooled-data training over internet connections and with consumer-grade hardware.