# Position: AI Agents in Scientific Teams Should Be Studied as Human-Agent Systems

arXiv: https://arxiv.org/abs/2608.14667 · HTML: https://mlsanity.com/paper/2608.14667/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Web, search, and research agents, one of 16 directions in LLM agents and tool use.
- Builds on 58 of its 80 references that are in the map.
- First posted on arXiv 2 Aug 2026.

## Placed in

- LLM agents and tool use / [Web, search, and research agents](https://mlsanity.com/agents/web-search-and-research-agents/)

## Builds on (most cited first, 30 of 58)

- [The AI Scientist: Towards Fully Automated Open-Ended Scientific Discovery](https://mlsanity.com/paper/2408.06292/) (2024)
- [Agent Laboratory: Using LLM Agents as Research Assistants](https://mlsanity.com/paper/2501.04227/) (2025)
- [The AI Scientist-v2: Workshop-Level Automated Scientific Discovery via Agentic Tree Search](https://mlsanity.com/paper/2504.08066/) (2025)
- [Does the Whole Exceed its Parts? The Effect of AI Explanations on Complementary Team Performance](https://mlsanity.com/paper/2006.14779/) (2020)
- [MINT: Evaluating LLMs in Multi-turn Interaction with Tools and Language Feedback](https://mlsanity.com/paper/2309.10691/) (2023)
- [Poisoning Web-Scale Training Datasets is Practical](https://mlsanity.com/paper/2302.10149/) (2023)
- [MART: Improving LLM Safety with Multi-round Automatic Red-Teaming](https://mlsanity.com/paper/2311.07689/) (2023)
- [CycleResearcher: Improving Automated Research via Automated Review](https://mlsanity.com/paper/2411.00816/) (2024)
- [Empowering Biomedical Discovery with AI Agents](https://mlsanity.com/paper/2404.02831/) (2024)
- [When combinations of humans and AI are useful: A systematic review and meta-analysis](https://mlsanity.com/paper/2405.06087/) (2024)
- [AI-Researcher: Autonomous Scientific Innovation](https://mlsanity.com/paper/2505.18705/) (2025)
- [Towards Scientific Intelligence: A Survey of LLM-based Scientific Agents](https://mlsanity.com/paper/2503.24047/) (2025)
- [From Automation to Autonomy: A Survey on Large Language Models in Scientific Discovery](https://mlsanity.com/paper/2505.13259/) (2025)
- [Kosmos: An AI Scientist for Autonomous Discovery](https://mlsanity.com/paper/2511.02824/) (2025)
- [From AI for Science to Agentic Science: A Survey on Autonomous Scientific Discovery](https://mlsanity.com/paper/2508.14111/) (2025)
- [AgentRxiv: Towards Collaborative Autonomous Research](https://mlsanity.com/paper/2503.18102/) (2025)
- [Poisoning Attacks on LLMs Require a Near-constant Number of Poison Samples](https://mlsanity.com/paper/2510.07192/) (2025)
- [Many Heads Are Better Than One: Improved Scientific Idea Generation by A LLM-Based Multi-Agent System](https://mlsanity.com/paper/2410.09403/) (2024)
- [Collaborative Gym: A Framework for Enabling and Evaluating Human-Agent Collaboration](https://mlsanity.com/paper/2412.15701/) (2024)
- [DeepScientist: Advancing Frontier-Pushing Scientific Findings Progressively](https://mlsanity.com/paper/2509.26603/) (2025)
- [ORGANA: A Robotic Assistant for Automated Chemistry Experimentation and Characterization](https://mlsanity.com/paper/2401.06949/) (2024)
- [CodeScientist: End-to-End Semi-Automated Scientific Discovery with Code-based Experimentation](https://mlsanity.com/paper/2503.22708/) (2025)
- [Autonomous LLM-driven research from data to human-verifiable research papers](https://mlsanity.com/paper/2404.17605/) (2024)
- [AstaBench: Rigorous Benchmarking of AI Agents with a Scientific Research Suite](https://mlsanity.com/paper/2510.21652/) (2025)
- [EvoScientist: Towards Multi-Agent Evolving AI Scientists for End-to-End Scientific Discovery](https://mlsanity.com/paper/2603.08127/) (2026)
- [InternAgent: When Agent Becomes the Scientist -- Building Closed-Loop System from Hypothesis to Verification](https://mlsanity.com/paper/2505.16938/) (2025)
- [El Agente: An Autonomous Agent for Quantum Chemistry](https://mlsanity.com/paper/2505.02484/) (2025)
- [Early science acceleration experiments with GPT-5](https://mlsanity.com/paper/2511.16072/) (2025)
- [Complementarity in Human-AI Collaboration: Concept, Sources, and Evidence](https://mlsanity.com/paper/2404.00029/) (2024)
- [CoQuest: Exploring Research Question Co-Creation with an LLM-based Agent](https://mlsanity.com/paper/2310.06155/) (2023)

## Abstract (arXiv)

Large language model-based agents are increasingly deployed as collaborators in scientific discovery yet most current work focuses on the autonomous capabilities of "AI Scientists". We argue that this overlooks the social aspects of scientific teamwork, and that studying AI Scientists as human-agent systems (HAS)--where the unit of analysis is the human-agent pair--is both underexplored and undervalued. We establish these points through literature and empirical analysis, and highlight recent incidences and studies which show that deploying agents in science without accounting for human-agent dynamics introduces near-term risks, including reduced diversity of scientific inquiry. Through analysis of real-world case studies, we show that scientists and agents can augment each other's capabilities. We call for new research that adopts the HAS lens to develop mathematical frameworks for understanding and fostering human-AI synergy in scientific discovery.