# Disentangled Shared Representations Improve Morpho-Transcriptomic Integration

arXiv: https://arxiv.org/abs/2608.14355 · HTML: https://mlsanity.com/paper/2608.14355/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 8 of its 22 references that are in the map.
- First posted on arXiv 14 Aug 2026.

## Builds on (most cited first, 8 of 8)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [LeWorldModel: Stable End-to-End Joint-Embedding Predictive Architecture from Pixels](https://mlsanity.com/paper/2603.19312/) (2026)
- [Variational Mixture-of-Experts Autoencoders for Multi-Modal Deep Generative Models](https://mlsanity.com/paper/1911.03393/) (2019)
- [HEST-1k: A Dataset for Spatial Transcriptomics and Histology Image Analysis](https://mlsanity.com/paper/2406.16192/) (2024)
- [Spatially Resolved Gene Expression Prediction from H&E Histology Images via Bi-modal Contrastive Learning](https://mlsanity.com/paper/2306.01859/) (2023)
- [Diffusion Generative Modeling for Spatially Resolved Gene Expression Inference from Histology Images](https://mlsanity.com/paper/2501.15598/) (2025)
- [An Information Criterion for Controlled Disentanglement of Multimodal Data](https://mlsanity.com/paper/2410.23996/) (2024)
- [Disentangling shared and private latent factors in multimodal Variational Autoencoders](https://mlsanity.com/paper/2403.06338/) (2024)

## Abstract (arXiv)

Spatial transcriptomics (ST) enables the simultaneous profiling of gene expression and tissue morphology, creating an opportunity to learn multimodal representations capturing shared morpho-transcriptomic structure. However, standard multimodal models often compress modalities into a common latent space without explicitly separating shared and modality-specific sources of variation, which may limit downstream utility. We investigate whether explicit disentanglement of shared and private latent components improves multimodal representation learning for paired Hematoxylin & Eosin (H&E) and ST data. We compare VAE-based and contrastive approaches, each in standard and disentangled variants, across two cancer cohorts under matched experimental conditions. Representations are evaluated using cross-modal reconstruction, downstream probing and cross-modal probe transfer. The experiments suggest two main trends. First, contrastive objectives yield higher downstream probing performance than VAE-based models. Second, disentangled variants improve the selected reconstruction and probing metrics, although the gains depend on the model family, task, direction, and disentanglement strength. Overall, our results suggest that explicitly factorizing shared and modality-specific information can improve multimodal representation learning for spatial transcriptomics and provides a useful evaluation framework for future foundation models.