# Learning Unsteady Aneurysm Hemodynamics with Physics-Informed DeepONets

arXiv: https://arxiv.org/abs/2608.13629 · HTML: https://mlsanity.com/paper/2608.13629/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 22 of its 51 references that are in the map.
- First posted on arXiv 13 Aug 2026.

## Builds on (most cited first, 22 of 22)

- [Model-Agnostic Meta-Learning for Fast Adaptation of Deep Networks](https://mlsanity.com/paper/1703.03400/) (2017)
- [Delving Deep into Rectifiers: Surpassing Human-Level Performance on ImageNet Classification](https://mlsanity.com/paper/1502.01852/) (2015)
- [Fourier Features Let Networks Learn High Frequency Functions in Low Dimensional Domains](https://mlsanity.com/paper/2006.10739/) (2020)
- [DeepONet: Learning nonlinear operators for identifying differential equations based on the universal approximation theorem of operators](https://mlsanity.com/paper/1910.03193/) (2019)
- [Learning the solution operator of parametric partial differential equations with physics-informed DeepOnets](https://mlsanity.com/paper/2103.10974/) (2021)
- [On the eigenvector bias of Fourier feature networks: From regression to solving multi-scale PDEs with physics-informed neural networks](https://mlsanity.com/paper/2012.10047/) (2020)
- [MIONet: Learning multiple-input operators via tensor product](https://mlsanity.com/paper/2202.06137/) (2022)
- [Physics-Informed Deep Neural Operator Networks](https://mlsanity.com/paper/2207.05748/) (2022)
- [Long-time integration of parametric evolution equations with physics-informed DeepONets](https://mlsanity.com/paper/2106.05384/) (2021)
- [Improved architectures and training algorithms for deep operator networks](https://mlsanity.com/paper/2110.01654/) (2021)
- [Gradient Alignment in Physics-informed Neural Networks: A Second-Order Optimization Perspective](https://mlsanity.com/paper/2502.00604/) (2025)
- [Sequential Deep Operator Networks (S-DeepONet) for Predicting Full-field Solutions Under Time-dependent Loads](https://mlsanity.com/paper/2306.08218/) (2023)
- [CFDBench: A Large-Scale Benchmark for Machine Learning Methods in Fluid Dynamics](https://mlsanity.com/paper/2310.05963/) (2023)
- [Transformers as Neural Operators for Solutions of Differential Equations with Finite Regularity](https://mlsanity.com/paper/2405.19166/) (2024)
- [One-shot learning for solution operators of partial differential equations](https://mlsanity.com/paper/2104.05512/) (2021)
- [Self-adaptive weights based on balanced residual decay rate for physics-informed neural networks and deep operator networks](https://mlsanity.com/paper/2407.01613/) (2024)
- [Predictions of Transient Vector Solution Fields with Sequential Deep Operator Network](https://mlsanity.com/paper/2311.11500/) (2023)
- [Temporal Neural Operator for Modeling Time-Dependent Physical Phenomena](https://mlsanity.com/paper/2504.20249/) (2025)
- [3D Neural Operator-Based Flow Surrogates around 3D geometries: Signed Distance Functions and Derivative Constraints](https://mlsanity.com/paper/2503.17289/) (2025)
- [Enhanced Vascular Flow Simulations in Aortic Aneurysm via Physics-Informed Neural Networks and Deep Operator Networks](https://mlsanity.com/paper/2503.17402/) (2025)
- [Physics-Informed DeepONet Coupled with FEM for Convective Transport in Porous Media with Sharp Gaussian Sources](https://mlsanity.com/paper/2508.19847/) (2025)
- [PO-CKAN:Physics Informed Deep Operator Kolmogorov Arnold Networks with Chunk Rational Structure](https://mlsanity.com/paper/2510.08795/) (2025)

## Abstract (arXiv)

Clinically actionable, patient-specific hemodynamic assessment, specifically wall shear stress, vortex structure and pressure distributions, is critical for determining risky or unfavorable evolution in Abdominal Aortic Aneurysms (AAA). While Physics-Informed Deep Operator Networks (PI-DeepONets) show promising results in complementing established 5 tools such as Computational Fluid Dynamics (CFD), a persistent architectural challenge remains for complex 3D flows. In this direction, we propose a Modified Multi-Input Multi-Output PI-DeepONets (M3PI-DeepONet) designed for predicting unsteady flows in an idealized AAA geometry. Central to our model is the Aggregated Injection strategy, where latent representations from multiple input branches are fused prior to trunk injection, allowing the coordinate basis to adapt to multiple physical constraints. To the best of our knowledge, this is the first architecture to combine the layer-wise gating mechanism with a multi-branch operator-network topology, yielding an input-adaptive trunk basis. Additionally, we integrate the 3D Navier-Stokes equations as governing physical laws, so the model is trained based on physics-informed residuals, initial and boundary conditions, and only 0.3% of the labeled internal data together with the selected branch-conditioning signals. The M3PI-DeepONet simultaneously predicts unsteady 3D flow velocity and pressure fields with an average relative L2 velocity error below 4% and pressure error around 5% while achieving a conservative retained-cycle inference speedup of approximately 36x compared to reference CFD simulations once the branch inputs used for conditioning are available. This work advances the application of deep learning in cardiovascular disease modeling, marking step toward real-time, non-invasive clinical diagnostics.