# Intervention-Aware Clinical World Model for Post-Op Outcome Forecasting in Cardiology

arXiv: https://arxiv.org/abs/2608.13518 · HTML: https://mlsanity.com/paper/2608.13518/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 13 of its 26 references that are in the map.
- First posted on arXiv 13 Aug 2026.

## Builds on (most cited first, 13 of 13)

- [Genie: Generative Interactive Environments](https://mlsanity.com/paper/2402.15391/) (2024)
- [Revisiting Feature Prediction for Learning Visual Representations from Video](https://mlsanity.com/paper/2404.08471/) (2024)
- [An Electrocardiogram Foundation Model Built on over 10 Million Recordings with External Evaluation across Multiple Domains](https://mlsanity.com/paper/2410.04133/) (2024)
- [AtrialJSQnet: A New Framework for Joint Segmentation and Quantification of Left Atrium and Scars Incorporating Spatial and Shape Information](https://mlsanity.com/paper/2008.04729/) (2020)
- [CheXWorld: Exploring Image World Modeling for Radiograph Representation Learning](https://mlsanity.com/paper/2504.13820/) (2025)
- [EHRWorld: A Patient-Centric Medical World Model for Long-Horizon Clinical Trajectories](https://mlsanity.com/paper/2602.03569/) (2026)
- [Cardiac Copilot: Automatic Probe Guidance for Echocardiography with World Model](https://mlsanity.com/paper/2406.13165/) (2024)
- [EchoWorld: Learning Motion-Aware World Models for Echocardiography Probe Guidance](https://mlsanity.com/paper/2504.13065/) (2025)
- [MuDreamer: Learning Predictive World Models without Reconstruction](https://mlsanity.com/paper/2405.15083/) (2024)
- [Beyond Generative AI: World Models for Clinical Prediction, Counterfactuals, and Planning](https://mlsanity.com/paper/2511.16333/) (2025)
- [Generative Artificial Intelligence in Medical Imaging: Foundations, Progress, and Clinical Translation](https://mlsanity.com/paper/2508.09177/) (2025)
- [SOFA: Deep Learning Framework for Simulating and Optimizing Atrial Fibrillation Ablation](https://mlsanity.com/paper/2508.07621/) (2025)
- [CRAFT: Clinical Reward-Aligned Finetuning for Medical Image Synthesis](https://mlsanity.com/paper/2605.12650/) (2026)

## Built on by (most cited first, 1 of 1)

- [PatientWM: Towards Generalizable Clinical World Models via Unified Patient States](https://mlsanity.com/paper/2610.17059/) (2026)

## Abstract (arXiv)

Many clinical prediction models treat post-intervention outcomes as a one-step mapping from baseline measurements to a future endpoint. However, recovery after a procedure often unfolds as an irregular trajectory: clinical observations, medication changes, repeat interventions, and physiological measurements are recorded asynchronously and can change risk assessment over time. We propose an intervention-aware clinical world model that represents each patient with a structured latent state and evolves it through time-ordered post-intervention events. The model first encodes baseline imaging into a 3D spatial latent state. It then updates this state using procedural context, static covariates, elapsed time, and peri-event physiological embeddings. Follow-up imaging provides training-only supervision through a latent forecasting objective. We apply the framework to atrial fibrillation ablation. During the 90-day recovery window, irregular post-procedure records provide clinically meaningful evidence for long-term recurrence risk. In repeated internal cross-validation on DECAAF-II, our model achieves AUROC 0.756 and AUPRC 0.777 for recurrence prediction. It also achieves a scar-extent MAE of 2.971 percentage points without requiring follow-up MRI intensities at inference. The learned state supports recurrence-risk queries at different horizons and retrospective input editing of blanking-period records.