# Explainable Machine Learning in Healthcare: Methods, Interpretation, and Applications for Clinical Research

arXiv: https://arxiv.org/abs/2608.07522 · HTML: https://mlsanity.com/paper/2608.07522/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 13 of its 45 references that are in the map.
- First posted on arXiv 13 Jul 2026.

## Builds on (most cited first, 13 of 13)

- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [A Unified Approach to Interpreting Model Predictions](https://mlsanity.com/paper/1705.07874/) (2017)
- [XGBoost: A Scalable Tree Boosting System](https://mlsanity.com/paper/1603.02754/) (2016)
- ["Why Should I Trust You?": Explaining the Predictions of Any Classifier](https://mlsanity.com/paper/1602.04938/) (2016)
- [Towards A Rigorous Science of Interpretable Machine Learning](https://mlsanity.com/paper/1702.08608/) (2017)
- [Explaining Explanations: An Overview of Interpretability of Machine Learning](https://mlsanity.com/paper/1806.00069/) (2018)
- [Confounding variables can degrade generalization performance of radiological deep learning models](https://mlsanity.com/paper/1807.00431/) (2018)
- [Explainable Machine Learning for Scientific Insights and Discoveries](https://mlsanity.com/paper/1905.08883/) (2019)
- [Why Is My Classifier Discriminatory?](https://mlsanity.com/paper/1805.12002/) (2018)
- [Interpretable classifiers using rules and Bayesian analysis: Building a better stroke prediction model](https://mlsanity.com/paper/1511.01644/) (2015)
- [Principles and Practice of Explainable Machine Learning](https://mlsanity.com/paper/2009.11698/) (2020)
- [Scalable Bayesian Rule Lists](https://mlsanity.com/paper/1602.08610/) (2016)
- [Explainable AI, but explainable to whom?](https://mlsanity.com/paper/2106.05568/) (2021)

## Abstract (arXiv)

We present a structured review of commonly used Explainable machine learning (XML) methodologies, including global and local interpretability tools such as SHapley Additive exPlanations (SHAP), Local Interpretable Model-Agnostic Explanations (LIME), Partial Dependence Plots (PDP), and Individual Conditional Expectation (ICE) plots. For each method, we explain the underlying mechanism at a high level, visualize representative outputs, and provide structured guidance on interpretation, appropriate use, and limitations, illustrated using the publicly available Heart Disease dataset. XML techniques provided intuitive visual and quantitative insights into how predictors influence model predictions. Global methods characterized population-level feature effects, whereas local methods revealed patient-level contributions useful for individualized interpretation. Our worked examples demonstrate how XML outputs can identify nonlinear relationships, detect interaction effects, and reveal heterogeneity in predicted risk across patients, addressing key challenges in translating ML predictions into interpretable outputs for clinical research. XML tools offer valuable interpretability for ML models and support more transparent and accountable ML applications in clinical research. By providing a methodologically grounded overview alongside practical implementation examples and structured guidance on each method's strengths and limitations, this primer helps bridge the gap between advanced ML methodology and clinical applicability. Thoughtful adoption of XML approaches may facilitate better understanding, communication, and critical evaluation of ML predictions in healthcare research, ultimately supporting evidence-based clinical decision-making.