# FedDOSE: Federated Learning Framework Decomposing Site Effects for Modeling Brain Dynamic Functional Connectivity

arXiv: https://arxiv.org/abs/2608.07393 · HTML: https://mlsanity.com/paper/2608.07393/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 14 of its 47 references that are in the map.
- First posted on arXiv 7 Aug 2026.

## Builds on (most cited first, 14 of 14)

- [Communication-Efficient Learning of Deep Networks from Decentralized Data](https://mlsanity.com/paper/1602.05629/) (2016)
- [Unsupervised Domain Adaptation by Backpropagation](https://mlsanity.com/paper/1409.7495/) (2014)
- [Personalized Federated Learning with Moreau Envelopes](https://mlsanity.com/paper/2006.08848/) (2020)
- [FedProto: Federated Prototype Learning across Heterogeneous Clients](https://mlsanity.com/paper/2105.00243/) (2021)
- [Communication-Efficient On-Device Machine Learning: Federated Distillation and Augmentation under Non-IID Private Data](https://mlsanity.com/paper/1811.11479/) (2018)
- [Multi-Institutional Deep Learning Modeling Without Sharing Patient Data: A Feasibility Study on Brain Tumor Segmentation](https://mlsanity.com/paper/1810.04304/) (2018)
- [Federated Evaluation of On-device Personalization](https://mlsanity.com/paper/1910.10252/) (2019)
- [Multi-site fMRI Analysis Using Privacy-preserving Federated Learning and Domain Adaptation: ABIDE Results](https://mlsanity.com/paper/2001.05647/) (2020)
- [Scanner Invariant Representations for Diffusion MRI Harmonization](https://mlsanity.com/paper/1904.05375/) (2019)
- [FedNI: Federated Graph Learning with Network Inpainting for Population-Based Disease Prediction](https://mlsanity.com/paper/2112.10166/) (2021)
- [Energy-Guided Continuous Entropic Barycenter Estimation for General Costs](https://mlsanity.com/paper/2310.01105/) (2023)
- [Preserving Specificity in Federated Graph Learning for fMRI-based Neurological Disorder Identification](https://mlsanity.com/paper/2308.10302/) (2023)
- [FedAli: Personalized Federated Learning Alignment with Prototype Layers for Generalized Mobile Services](https://mlsanity.com/paper/2411.10595/) (2024)
- [Tensor Decomposition based Personalized Federated Learning](https://mlsanity.com/paper/2208.12959/) (2022)

## Abstract (arXiv)

Functional Magnetic Resonance Imaging ( fMRI ) data are often pooled into collaborative multi-site consortia, as deep learning models for analyses require large datasets to generalize well. While Federated Learning (FL) offers a privacy-preserving paradigm for collaborative training, standard approaches continue to struggle with statistical heterogeneity. In particular, site differences pose a key challenge in multi-site data settings. Additionally, existing FL approaches for fMRI rely on static Functional Connectivity ( FC), omitting dynamic information in brain networks. To address this, we propose FedDOSE, a novel framework that explicitly decomposes site differences for analysis of dynamic FC (dFC). FedDOSE introduces a Modularity-Guided Tucker Decomposition block to encode high-dimensional dFC tensors and capture modular-level spatio-temporal patterns efficiently. Class-specific prototypes are generated across all sites and subsequently aligned at the global level by using a combination of Optimal Transport (OT) barycenter formulation and Procrustes analysis. Extensive experiments for diagnosing Autism Spectrum Disorder (ASD) and Attention-Deficit Hyperactivity Disorder (ADHD) on three multi-site resting-state fMRI datasets: ABIDE-I, ABIDE-II, and ADHD-200, demonstrate that FedDOSE outperforms state-of-the-art methods in ASD and ADHD detection. Our results highlight its effectiveness in learning robust representations from multi-site datasets for reliable analysis.