# TumorBoard: Evidence-Grounded Multi-Agent Decision Support for Longitudinal Neuro-Oncology

arXiv: https://arxiv.org/abs/2608.03190 · HTML: https://mlsanity.com/paper/2608.03190/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 15 of its 39 references that are in the map.
- First posted on arXiv 4 Aug 2026.

## Builds on (most cited first, 15 of 15)

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- [Large Language Models as Agents in the Clinic](https://mlsanity.com/paper/2309.10895/) (2023)

## Abstract (arXiv)

Neuro-oncology decisions require coordinated interpretation of serial MRI, pathology, molecular markers, treatment history, performance status, and evolving guidelines. We present TumorBoard, a multi-agent decision-support system built around a shared longitudinal case state and an auditable claim-evidence ledger. Specialist agents for radiology, neuropathology, molecular diagnosis, guidelines, and therapy planning produce atomic claims with provenance. An adversarial critic exposes contradictions, and a safety governor releases, qualifies, or defers recommendations according to evidence sufficiency and temporal validity. On a 360-case hidden benchmark at a matched token budget, TumorBoard achieved an action F1 of 0.772 and evidence entailment of 0.914. It exceeded the strongest typed-council baseline by 3.1 percentage points (95% CI: 1.6 to 4.7, adjusted p = 0.0012), while recommendation-to-evidence coverage reached 0.927. Under evidence deletion, the system deferred 84.2% of unsafe cases and limited harmful recommendations to 5.8%. The safety governor reduced harmful release by 7.8 percentage points at a false-deferral cost of 4.3 percentage points. Ablation studies of the ledger, critic, and governor produced the predicted failure patterns, establishing structured coordination as the source of the measured multi-agent advantage.