# DynoDINO: Harnessing Dynamic Latent Information from DINO Features for Multi-Phase Medical Image Segmentation

arXiv: https://arxiv.org/abs/2607.29568 · HTML: https://mlsanity.com/paper/2607.29568/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 26 of its 48 references that are in the map.
- First posted on arXiv 31 Jul 2026.

## Builds on (most cited first, 26 of 26)

- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [DINOv2: Learning Robust Visual Features without Supervision](https://mlsanity.com/paper/2304.07193/) (2023)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [FlashAttention: Fast and Memory-Efficient Exact Attention with IO-Awareness](https://mlsanity.com/paper/2205.14135/) (2022)
- [SegFormer: Simple and Efficient Design for Semantic Segmentation with Transformers](https://mlsanity.com/paper/2105.15203/) (2021)
- [FlashAttention-2: Faster Attention with Better Parallelism and Work Partitioning](https://mlsanity.com/paper/2307.08691/) (2023)
- [Non-local Neural Networks](https://mlsanity.com/paper/1711.07971/) (2017)
- [V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentation](https://mlsanity.com/paper/1606.04797/) (2016)
- [Informer: Beyond Efficient Transformer for Long Sequence Time-Series Forecasting](https://mlsanity.com/paper/2012.07436/) (2020)
- [SlowFast Networks for Video Recognition](https://mlsanity.com/paper/1812.03982/) (2018)
- [DINOv3](https://mlsanity.com/paper/2508.10104/) (2025)
- [UNETR: Transformers for 3D Medical Image Segmentation](https://mlsanity.com/paper/2103.10504/) (2021)
- [Efficient Transformers: A Survey](https://mlsanity.com/paper/2009.06732/) (2020)
- [VoxelMorph: A Learning Framework for Deformable Medical Image Registration](https://mlsanity.com/paper/1809.05231/) (2018)
- [The Liver Tumor Segmentation Benchmark (LiTS)](https://mlsanity.com/paper/1901.04056/) (2019)
- [Remote Sensing Image Change Detection with Transformers](https://mlsanity.com/paper/2103.00208/) (2021)
- [nnU-Net: Self-adapting Framework for U-Net-Based Medical Image Segmentation](https://mlsanity.com/paper/1809.10486/) (2018)
- [Deep Learning in Medical Image Registration: A Survey](https://mlsanity.com/paper/1903.02026/) (2019)
- [A review: Deep learning for medical image segmentation using multi-modality fusion](https://mlsanity.com/paper/2004.10664/) (2020)
- [Modality-aware Mutual Learning for Multi-modal Medical Image Segmentation](https://mlsanity.com/paper/2107.09842/) (2021)
- [MedDINOv3: How to adapt vision foundation models for medical image segmentation?](https://mlsanity.com/paper/2509.02379/) (2025)
- [TransFusion: Multi-view Divergent Fusion for Medical Image Segmentation with Transformers](https://mlsanity.com/paper/2203.10726/) (2022)
- [Dino U-Net: Exploiting High-Fidelity Dense Features from Foundation Models for Medical Image Segmentation](https://mlsanity.com/paper/2508.20909/) (2025)
- [Deep Learning for fully automatic detection, segmentation, and Gleason Grade estimation of prostate cancer in multiparametric Magnetic Resonance Images](https://mlsanity.com/paper/2103.12650/) (2021)
- [Is attention all you need in medical image analysis? A review](https://mlsanity.com/paper/2307.12775/) (2023)

## Abstract (arXiv)

Multi-phase Contrast-Enhanced Computed Tomography (CECT) plays a central role in the diagnosis and characterization of focal lesions by capturing temporal enhancement patterns across multiple acquisition phases. Accurate lesion segmentation from such data remains challenging because clinically relevant contrast kinetics are distributed across phases, while anatomical inconsistencies, respiratory motion, and incomplete acquisitions often lead to inter-phase misalignment and interrupted temporal information. Conventional segmentation frameworks typically process each phase independently or rely on simple fusion strategies, limiting their temporal reasoning capability. To address these challenges, we propose DynoDINO, a unified framework tailored to address the core challenges of multi-phase medical image segmentation. DynoDINO first performs slice-level alignment to establish inter-phase anatomical correspondence and then employs a Multi-phase Fusion Model to jointly enhance temporal correlations across phases. Our fusion model incorporates a Mix-attention (MA) mechanism for efficient multi-phase feature calibration and an Adaptive Gating Mechanism with difference-based residual learning to selectively preserve diagnostically relevant contrast variations while suppressing artifacts caused by residual misalignment. In addition, the adaptive gating mechanism improves training stability by preventing feature degradation caused by unguided subtraction operations. Experiments on three large-scale datasets, including LiTS, PLC-CECT, and WAW-TACE, demonstrate that DynoDINO consistently improves boundary delineation and structural fidelity under standard, shifted, and missing-phase conditions.