# NeuroSynth: A Biologically Inspired Continual Reinforcement Learning Architecture for Mitigating Catastrophic Forgetting

arXiv: https://arxiv.org/abs/2607.28663 · HTML: https://mlsanity.com/paper/2607.28663/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Deep RL algorithms and representations, one of 15 directions in Deep reinforcement learning methods.
- Builds on 10 of its 21 references that are in the map.
- First posted on arXiv 24 Jul 2026.

## Placed in

- Deep reinforcement learning methods / [Deep RL algorithms and representations](https://mlsanity.com/deeprl/deep-rl-algorithms-and-representations/)

## Builds on (most cited first, 10 of 10)

- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [Proximal Policy Optimization Algorithms](https://mlsanity.com/paper/1707.06347/) (2017)
- [Distilling the Knowledge in a Neural Network](https://mlsanity.com/paper/1503.02531/) (2015)
- [Overcoming catastrophic forgetting in neural networks](https://mlsanity.com/paper/1612.00796/) (2016)
- [Learning without Forgetting](https://mlsanity.com/paper/1606.09282/) (2016)
- [Progressive Neural Networks](https://mlsanity.com/paper/1606.04671/) (2016)
- [Continual Lifelong Learning with Neural Networks: A Review](https://mlsanity.com/paper/1802.07569/) (2018)
- [Experience Replay for Continual Learning](https://mlsanity.com/paper/1811.11682/) (2018)
- [An Empirical Investigation of Catastrophic Forgetting in Gradient-Based Neural Networks](https://mlsanity.com/paper/1312.6211/) (2013)
- [Towards Continual Reinforcement Learning: A Review and Perspectives](https://mlsanity.com/paper/2012.13490/) (2020)

## Abstract (arXiv)

Artificial Intelligence (AI) systems often perform well on isolated tasks but struggle under continual learning conditions, where training on new tasks can overwrite previously acquired knowledge, a failure mode known as catastrophic forgetting. Biological learning systems reduce this interference through complementary memory processes involving rapid hippocampal encoding and slower cortical consolidation. This study introduces NeuroSynth, a brain-inspired continual reinforcement learning architecture designed to mitigate catastrophic forgetting through a dual-pathway consolidation mechanism. NeuroSynth separates rapid task acquisition from long-term retention using distinct "plan" and "habit" pathways combined with replay and knowledge distillation. NeuroSynth was evaluated against Proximal Policy Optimization (PPO) and Elastic Weight Consolidation (EWC) across three sequential navigation tasks with changing goal locations in a non-revisitation continual learning setting. Across six independent seeds, NeuroSynth preserved substantially more early-task knowledge than PPO after sequential training, achieving 18.00% Task A success rate compared to 0.33% for PPO (p = 0.014929, Cohen's d = 1.49) and 35.33% Task B success rate compared to 0.00% for PPO (p = 0.002376, Cohen's d = 2.31). NeuroSynth also demonstrated higher final Task C performance than EWC, achieving 9.00% compared to 2.00% (p = 0.226643, Cohen's d = 0.56), indicating a moderate but not statistically significant advantage. These findings suggest that biologically inspired consolidation mechanisms may improve the stability-plasticity balance in continual reinforcement learning systems.