# Towards Practical Algorithm Selection for Unsupervised Domain Adaptation in Medical Imaging

arXiv: https://arxiv.org/abs/2607.28125 · HTML: https://mlsanity.com/paper/2607.28125/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 19 of its 34 references that are in the map.
- First posted on arXiv 30 Jul 2026.

## Builds on (most cited first, 19 of 19)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [Domain-Adversarial Training of Neural Networks](https://mlsanity.com/paper/1505.07818/) (2015)
- [Unsupervised Domain Adaptation by Backpropagation](https://mlsanity.com/paper/1409.7495/) (2014)
- [Learning Transferable Features with Deep Adaptation Networks](https://mlsanity.com/paper/1502.02791/) (2015)
- [ChestX-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseases](https://mlsanity.com/paper/1705.02315/) (2017)
- [Maximum Classifier Discrepancy for Unsupervised Domain Adaptation](https://mlsanity.com/paper/1712.02560/) (2017)
- [VisDA: The Visual Domain Adaptation Challenge](https://mlsanity.com/paper/1710.06924/) (2017)
- [Towards Discriminability and Diversity: Batch Nuclear-norm Maximization under Label Insufficient Situations](https://mlsanity.com/paper/2003.12237/) (2020)
- [Domain Adaptation with Auxiliary Target Domain-Oriented Classifier](https://mlsanity.com/paper/2007.04171/) (2020)
- [Minimal-Entropy Correlation Alignment for Unsupervised Deep Domain Adaptation](https://mlsanity.com/paper/1711.10288/) (2017)
- [Reusing the Task-specific Classifier as a Discriminator: Discriminator-free Adversarial Domain Adaptation](https://mlsanity.com/paper/2204.03838/) (2022)
- [Collaborative Unsupervised Domain Adaptation for Medical Image Diagnosis](https://mlsanity.com/paper/2007.07222/) (2020)
- [Tune it the Right Way: Unsupervised Validation of Domain Adaptation via Soft Neighborhood Density](https://mlsanity.com/paper/2108.10860/) (2021)
- [Unsupervised Domain Adaptation: A Reality Check](https://mlsanity.com/paper/2111.15672/) (2021)
- [Deep learning for unsupervised domain adaptation in medical imaging: Recent advancements and future perspectives](https://mlsanity.com/paper/2308.01265/) (2023)
- [Can We Evaluate Domain Adaptation Models Without Target-Domain Labels?](https://mlsanity.com/paper/2305.18712/) (2023)
- [Three New Validators and a Large-Scale Benchmark Ranking for Unsupervised Domain Adaptation](https://mlsanity.com/paper/2208.07360/) (2022)
- [Towards Accurate Model Selection in Deep Unsupervised Domain Adaptation](https://mlsanity.com/paper/2606.04665/) (2026)

## Abstract (arXiv)

Numerous unsupervised domain adaptation (UDA) algorithms exist, but for clinical practice, selecting the best-suited one along with proper hyperparameters often remains unclear, as the unlabeled deployment (target) domain prevents direct evaluation. We propose a label-free criterion that jointly selects the algorithm and hyperparameters for UDA. Given a pool of candidate models from multiple algorithms trained with different hyperparameters, our approach scores each candidate against an agreement reference, and selects the one with the highest score. The agreement reference is constructed in two levels without using target labels. First, we leverage multiple label-free selection signals, using each to nominate a model within every algorithm. Second, the nominated models are aggregated across algorithms to form a reference prediction for each unlabeled target sample. The candidate whose predictions agree most with this reference is then selected for deployment. Experimental results on four brain MRI and four chest X-ray datasets across seven clinically relevant transfer scenarios show that our method achieves better selection performance than other methods and remains effective across different algorithm pools. Our approach takes a step towards practical, label-free algorithm selection for clinical deployment of UDA.