# MedXplore: Towards Reliable and Unbiased Generalized Category Discovery in Medical Imaging

arXiv: https://arxiv.org/abs/2607.27620 · HTML: https://mlsanity.com/paper/2607.27620/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 24 of its 44 references that are in the map.
- First posted on arXiv 30 Jul 2026.

## Builds on (most cited first, 24 of 24)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [CosFace: Large Margin Cosine Loss for Deep Face Recognition](https://mlsanity.com/paper/1801.09414/) (2018)
- [Kvasir-SEG: A Segmented Polyp Dataset](https://mlsanity.com/paper/1911.07069/) (2019)
- [Recent Advances in Open Set Recognition: A Survey](https://mlsanity.com/paper/1811.08581/) (2018)
- [Open-World Semi-Supervised Learning](https://mlsanity.com/paper/2102.03526/) (2021)
- [A Unified Objective for Novel Class Discovery](https://mlsanity.com/paper/2108.08536/) (2021)
- [Common pitfalls and recommendations for using machine learning to detect and prognosticate for COVID-19 using chest radiographs and CT scans](https://mlsanity.com/paper/2008.06388/) (2020)
- [Learning to cluster in order to transfer across domains and tasks](https://mlsanity.com/paper/1711.10125/) (2017)
- [Neighborhood Contrastive Learning for Novel Class Discovery](https://mlsanity.com/paper/2106.10731/) (2021)
- [AutoNovel: Automatically Discovering and Learning Novel Visual Categories](https://mlsanity.com/paper/2106.15252/) (2021)
- [Parametric Classification for Generalized Category Discovery: A Baseline Study](https://mlsanity.com/paper/2211.11727/) (2022)
- [Novel Visual Category Discovery with Dual Ranking Statistics and Mutual Knowledge Distillation](https://mlsanity.com/paper/2107.03358/) (2021)
- [OpenMix: Reviving Known Knowledge for Discovering Novel Visual Categories in An Open World](https://mlsanity.com/paper/2004.05551/) (2020)
- [Federated Learning for Medical Image Analysis: A Survey](https://mlsanity.com/paper/2306.05980/) (2023)
- [Self-supervised learning methods and applications in medical imaging analysis: A survey](https://mlsanity.com/paper/2109.08685/) (2021)
- [SPTNet: An Efficient Alternative Framework for Generalized Category Discovery with Spatial Prompt Tuning](https://mlsanity.com/paper/2403.13684/) (2024)
- [Medical Image Fusion: A survey of the state of the art](https://mlsanity.com/paper/1401.0166/) (2013)
- [VORTEX: Physics-Driven Data Augmentations Using Consistency Training for Robust Accelerated MRI Reconstruction](https://mlsanity.com/paper/2111.02549/) (2021)
- [Decoding with Structured Awareness: Integrating Directional, Frequency-Spatial, and Structural Attention for Medical Image Segmentation](https://mlsanity.com/paper/2512.05494/) (2025)
- [A Challenging Benchmark of Anime Style Recognition](https://mlsanity.com/paper/2204.14034/) (2022)
- [TouchFormer: A Robust Transformer-based Framework for Multimodal Material Perception](https://mlsanity.com/paper/2511.19509/) (2025)

## Abstract (arXiv)

Deep learning has shown strong potential in medical image analysis, but most existing methods rely on large-scale annotations and a closed-world assumption that rarely holds in clinical practice. Although Generalized Category Discovery (GCD) has advanced rapidly on natural images, it remains underexplored in medical imaging. To address this issue, we propose MedXplore, a unified framework for reliable and unbiased medical GCD, optimizing from both perceptual and decision levels. Specifically, at the perceptual level, taking a frequency domain perspective, Frequency-SNR Adaptive Attention and Consistency (FAAC) performs learnable full-spectrum filtering and global-local energy contrast activation to not only highlight local abnormal signals relative to the global context, but also provide reliable semantic anchors for patch consistency learning. At the decision level, Adaptive Cosine-Angular Margin (ACAM) adjusts angular margins using semantic difficulty and feature confidence to balance intra-class compactness and inter-class separability. Together, the two modules improve lesion-sensitive representation learning and mitigate old-class bias. Experiments on multiple benchmarks show an average 8.5% gain in textitAll accuracy over the strongest competing methods. On Kvasir, MedXplore reduces false-old errors from 14.50% to 0.80%, demonstrating strong robustness under severe old-new ambiguity.