# Balanced Soft mixture-of-expert model for Glaucoma Detection

arXiv: https://arxiv.org/abs/2607.25324 · HTML: https://mlsanity.com/paper/2607.25324/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 21 of its 39 references that are in the map.
- First posted on arXiv 28 Jul 2026.

## Builds on (most cited first, 21 of 21)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [EfficientNet: Rethinking Model Scaling for Convolutional Neural Networks](https://mlsanity.com/paper/1905.11946/) (2019)
- [MobileNetV2: Inverted Residuals and Linear Bottlenecks](https://mlsanity.com/paper/1801.04381/) (2018)
- [Squeeze-and-Excitation Networks](https://mlsanity.com/paper/1709.01507/) (2017)
- [MobileNets: Efficient Convolutional Neural Networks for Mobile Vision Applications](https://mlsanity.com/paper/1704.04861/) (2017)
- [Outrageously Large Neural Networks: The Sparsely-Gated Mixture-of-Experts Layer](https://mlsanity.com/paper/1701.06538/) (2017)
- [Multimodal Machine Learning: A Survey and Taxonomy](https://mlsanity.com/paper/1705.09406/) (2017)
- [MnasNet: Platform-Aware Neural Architecture Search for Mobile](https://mlsanity.com/paper/1807.11626/) (2018)
- [Balanced Multimodal Learning via On-the-fly Gradient Modulation](https://mlsanity.com/paper/2203.15332/) (2022)
- [Low-Rank Few-Shot Adaptation of Vision-Language Models](https://mlsanity.com/paper/2405.18541/) (2024)
- [MoCo-CXR: MoCo Pretraining Improves Representation and Transferability of Chest X-ray Models](https://mlsanity.com/paper/2010.05352/) (2020)
- [LVM-Med: Learning Large-Scale Self-Supervised Vision Models for Medical Imaging via Second-order Graph Matching](https://mlsanity.com/paper/2306.11925/) (2023)
- [Dynamic Multimodal Fusion](https://mlsanity.com/paper/2204.00102/) (2022)
- [Classifier-guided Gradient Modulation for Enhanced Multimodal Learning](https://mlsanity.com/paper/2411.01409/) (2024)
- [On-the-fly Modulation for Balanced Multimodal Learning](https://mlsanity.com/paper/2410.11582/) (2024)
- [Harvard Glaucoma Fairness: A Retinal Nerve Disease Dataset for Fairness Learning and Fair Identity Normalization](https://mlsanity.com/paper/2306.09264/) (2023)
- [FairDomain: Achieving Fairness in Cross-Domain Medical Image Segmentation and Classification](https://mlsanity.com/paper/2407.08813/) (2024)
- [Deep Learning with HM-VGG: AI Strategies for Multi-modal Image Analysis](https://mlsanity.com/paper/2410.24046/) (2024)
- [MedMAE: A Self-Supervised Backbone for Medical Imaging Tasks](https://mlsanity.com/paper/2407.14784/) (2024)

## Abstract (arXiv)

Glaucoma is a group of eye diseases that damage the optic nerve, often caused by elevated intraocular pressure. It is a leading cause of irreversible vision loss and is typically developed slowly and painlessly, making it difficult to notice until significant damage has occurred. Therefore, early detection is crucial to prevent or slow the progression of vision loss. In recent years, deep learning based uni-modal models have improved the accuracy and efficiency of glaucoma detection, empowering doctors with tools for earlier diagnosis, better monitoring, and timely treatment. Building on this, multi-modal models have emerged, leveraging the strengths of different imaging modalities to learn richer and more robust representations, further enhancing glaucoma detection accuracy. However, multi-modal learning faces challenges such as imbalanced and under-optimized uni-modal representations due to joint learning objectives. To address this, we propose a balanced soft mixture-experts model with three experts and load balancing loss. The performance is measured by AUC, our proposed method surpasses the performance of all uni-modal baselines, conventional multi-modal models, and current stateof- the-art balanced multi-modal models. The proposed model can be generalized to other disease detections such as diabetic retinopathy.