# HantaWatch: Federated Learning for Hantavirus Genomic Surveillance

arXiv: https://arxiv.org/abs/2607.16234 · HTML: https://mlsanity.com/paper/2607.16234/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 2 of its 28 references that are in the map.
- First posted on arXiv 25 Jun 2026.

## Builds on (most cited first, 2 of 2)

- [Communication-Efficient Learning of Deep Networks from Decentralized Data](https://mlsanity.com/paper/1602.05629/) (2016)
- [Advances and Open Problems in Federated Learning](https://mlsanity.com/paper/1912.04977/) (2019)

## Abstract (arXiv)

Hantavirus genomic surveillance is limited by the distribution of sequence data, non-IID source heterogeneity, and constrained expert-review capacity. We propose HantaWatch, a federated learning framework that enables laboratories and surveillance sites to collaboratively train sequence-based models without sharing raw data. HantaWatch integrates k-mer feature extraction, source-aware federated client construction, adaptive DU-FedProx optimization, surveillance-specific model selection, and prediction-only triage. Experiments on binary and multi-class tasks show that HantaWatch supports high-risk screening, outbreak-associated prediction, clade classification, and clinical-syndrome categorization while balancing predictive performance, false-negative risk, and update stability. The framework converts model output into risk scores, confidence estimates, uncertainty flags, and ranked expert-review priorities. HantaWatch therefore provides a practical federated decision-support layer for decentralized Hantavirus surveillance, supporting expert prioritization without replacing laboratory or public-health interpretation.