# Exploring Post-Training Alignment of Small Language Models for Biomedical Data-to-Text Generation: A Case Study of Medication Leaflet

arXiv: https://arxiv.org/abs/2607.13430 · HTML: https://mlsanity.com/paper/2607.13430/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical LLM alignment, one of 10 directions in LLM alignment / RLHF / preference optimisation.
- Builds on 14 of its 23 references that are in the map.
- First posted on arXiv 15 Jul 2026.

## Placed in

- LLM alignment / RLHF / preference optimisation / [Medical LLM alignment](https://mlsanity.com/alignment/medical-llm-alignment/)

## Builds on (most cited first, 14 of 14)

- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
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- [Direct Preference Optimization: Your Language Model is Secretly a Reward Model](https://mlsanity.com/paper/2305.18290/) (2023)
- [Qwen2.5 Technical Report](https://mlsanity.com/paper/2412.15115/) (2024)
- [QLoRA: Efficient Finetuning of Quantized LLMs](https://mlsanity.com/paper/2305.14314/) (2023)
- [Understanding R1-Zero-Like Training: A Critical Perspective](https://mlsanity.com/paper/2503.20783/) (2025)
- [Group Sequence Policy Optimization](https://mlsanity.com/paper/2507.18071/) (2025)
- [ORPO: Monolithic Preference Optimization without Reference Model](https://mlsanity.com/paper/2403.07691/) (2024)
- [Parameter-Efficient Fine-Tuning Methods for Pretrained Language Models: A Critical Review and Assessment](https://mlsanity.com/paper/2312.12148/) (2023)
- [A Comprehensive Survey of Small Language Models in the Era of Large Language Models: Techniques, Enhancements, Applications, Collaboration with LLMs, and Trustworthiness](https://mlsanity.com/paper/2411.03350/) (2024)
- [Unintentional Unalignment: Likelihood Displacement in Direct Preference Optimization](https://mlsanity.com/paper/2410.08847/) (2024)
- [RS-DPO: A Hybrid Rejection Sampling and Direct Preference Optimization Method for Alignment of Large Language Models](https://mlsanity.com/paper/2402.10038/) (2024)
- [Instruction Fine-Tuning: Does Prompt Loss Matter?](https://mlsanity.com/paper/2401.13586/) (2024)
- [Biomedical Data-to-Text Generation via Fine-Tuning Transformers](https://mlsanity.com/paper/2109.01518/) (2021)

## Abstract (arXiv)

Translating complex biomedical data into patient-friendly narratives is central to modern biomedical informatics. This study presents a comparative analysis of training small language models (SLMs) in specialized biomedical datato-text generation tasks. We explore widely adopted post-training methods including supervised fine-tuning (SFT), direct preference optimization (DPO), odds ratio preference optimization (ORPO), and group relative policy optimization (GRPO) with Qwen-based SLMs on a medicine package leaflets dataset. To assess cross-dataset generalizability, we also curated drug label data from openFDA. We evaluate models using both standard lexical overlap metrics like ROUGE as well as semantic similarity measures. Across our experiments, the results show that (1) the aligned SLMs outperform proprietary models like GPT-5; (2) ORPO outperforms the SFTbaselines; (3) GRPO yields the most robust cross-dataset performance among the alignment methods tested as well as GPT-5.