# Improving Medical Image Generative Models with Fr'echet Distance Loss

arXiv: https://arxiv.org/abs/2607.13300 · HTML: https://mlsanity.com/paper/2607.13300/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 18 of its 26 references that are in the map.
- First posted on arXiv 14 Jul 2026.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 18 of 18)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Rethinking the Inception Architecture for Computer Vision](https://mlsanity.com/paper/1512.00567/) (2015)
- [Improved Techniques for Training GANs](https://mlsanity.com/paper/1606.03498/) (2016)
- [Demystifying MMD GANs](https://mlsanity.com/paper/1801.01401/) (2018)
- [BiomedCLIP: a multimodal biomedical foundation model pretrained from fifteen million scientific image-text pairs](https://mlsanity.com/paper/2303.00915/) (2023)
- [Identifying the Best Machine Learning Algorithms for Brain Tumor Segmentation, Progression Assessment, and Overall Survival Prediction in the BRATS Challenge](https://mlsanity.com/paper/1811.02629/) (2018)
- [The Liver Tumor Segmentation Benchmark (LiTS)](https://mlsanity.com/paper/1901.04056/) (2019)
- [MONAI: An open-source framework for deep learning in healthcare](https://mlsanity.com/paper/2211.02701/) (2022)
- [Rethinking FID: Towards a Better Evaluation Metric for Image Generation](https://mlsanity.com/paper/2401.09603/) (2023)
- [Anatomically-Controllable Medical Image Generation with Segmentation-Guided Diffusion Models](https://mlsanity.com/paper/2402.05210/) (2024)
- [Representation Fr'echet Loss for Visual Generation](https://mlsanity.com/paper/2604.28190/) (2026)
- [MedDINOv3: How to adapt vision foundation models for medical image segmentation?](https://mlsanity.com/paper/2509.02379/) (2025)
- [Feature Extraction for Generative Medical Imaging Evaluation: New Evidence Against an Evolving Trend](https://mlsanity.com/paper/2311.13717/) (2023)
- [Fr'echet Radiomic Distance (FRD): A Versatile Metric for Comparing Medical Imaging Datasets](https://mlsanity.com/paper/2412.01496/) (2024)
- [MedSegFactory: Text-Guided Generation of Medical Image-Mask Pairs](https://mlsanity.com/paper/2504.06897/) (2025)
- [Generative AI Enables Medical Image Segmentation in Ultra Low-Data Regimes](https://mlsanity.com/paper/2408.17421/) (2024)
- [MM-DINOv2: Adapting Foundation Models for Multi-Modal Medical Image Analysis](https://mlsanity.com/paper/2509.06617/) (2025)

## Built on by (most cited first, 1 of 1)

- [Does DCGAN-Based Synthetic Augmentation Improve Brain Tumor MRI Classification? An Empirical Study](https://mlsanity.com/paper/2609.28508/) (2026)

## Abstract (arXiv)

Diffusion generative models have demonstrated immense potential for synthetic medical image generation. However, these models often struggle to capture complex morphological characteristics of heterogeneous tumors with irregular boundaries, limiting their utility for downstream clinical tasks such as segmentation. This limitation stems from the standard denoising objective: minimizing a per-pixel error, which smooths high-variance irregular structures characteristic of tumors. To address this, we propose finetuning these generative models with Fr'echet Distance loss (FD-loss). FD-loss aligns the first and second order feature statistics of real and generated images in a pretrained encoder space, encouraging the generator to capture complex structural variations characteristic of heterogeneous tumors. We integrate FD-loss across diverse architectural settings, using both natural- and medical-image encoders on multiple liver and brain cancer datasets spanning CT and MRI modalities. Downstream segmentation networks trained on our FD-regularized synthetic data consistently achieve superior performance, improving tumor DSC by >5% over unregularized synthetic augmentation alone. Qualitative analysis suggests these gains are associated with more faithful tumor synthesis and fewer segmentation hallucinations. Our results show FD-loss as an effective regularizer for medical image generative models to improve clinical workflows.