# Controllable Generation of Diverse Dermatological Imagery for Fair and Efficient Malignancy Classification

arXiv: https://arxiv.org/abs/2607.12987 · HTML: https://mlsanity.com/paper/2607.12987/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 20 of its 27 references that are in the map.
- First posted on arXiv 14 Jul 2026.

## Builds on (most cited first, 20 of 20)

- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [The Unreasonable Effectiveness of Deep Features as a Perceptual Metric](https://mlsanity.com/paper/1801.03924/) (2018)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [DreamBooth: Fine Tuning Text-to-Image Diffusion Models for Subject-Driven Generation](https://mlsanity.com/paper/2208.12242/) (2022)
- [An Image is Worth One Word: Personalizing Text-to-Image Generation using Textual Inversion](https://mlsanity.com/paper/2208.01618/) (2022)
- [Demystifying MMD GANs](https://mlsanity.com/paper/1801.01401/) (2018)
- [SAM 3: Segment Anything with Concepts](https://mlsanity.com/paper/2511.16719/) (2025)
- [Evaluating Deep Neural Networks Trained on Clinical Images in Dermatology with the Fitzpatrick 17k Dataset](https://mlsanity.com/paper/2104.09957/) (2021)
- [Disparities in Dermatology AI: Assessments Using Diverse Clinical Images](https://mlsanity.com/paper/2111.08006/) (2021)
- [Kandinsky: an Improved Text-to-Image Synthesis with Image Prior and Latent Diffusion](https://mlsanity.com/paper/2310.03502/) (2023)
- [Generative models improve fairness of medical classifiers under distribution shifts](https://mlsanity.com/paper/2304.09218/) (2023)
- [Diffusion-based Data Augmentation for Skin Disease Classification: Impact Across Original Medical Datasets to Fully Synthetic Images](https://mlsanity.com/paper/2301.04802/) (2023)
- [Improving dermatology classifiers across populations using images generated by large diffusion models](https://mlsanity.com/paper/2211.13352/) (2022)
- [FairDisCo: Fairer AI in Dermatology via Disentanglement Contrastive Learning](https://mlsanity.com/paper/2208.10013/) (2022)
- [Augmenting medical image classifiers with synthetic data from latent diffusion models](https://mlsanity.com/paper/2308.12453/) (2023)
- [From Majority to Minority: A Diffusion-based Augmentation for Underrepresented Groups in Skin Lesion Analysis](https://mlsanity.com/paper/2406.18375/) (2024)
- [PatchAlign:Fair and Accurate Skin Disease Image Classification by Alignment with Clinical Labels](https://mlsanity.com/paper/2409.04975/) (2024)
- [FEDD -- Fair, Efficient, and Diverse Diffusion-based Lesion Segmentation and Malignancy Classification](https://mlsanity.com/paper/2307.11654/) (2023)
- [An Improved Method for Personalizing Diffusion Models](https://mlsanity.com/paper/2407.05312/) (2024)

## Abstract (arXiv)

Accurate dermatological diagnosis naturally necessitates equitable performance across diverse populations, yet a systematic lack of expertly annotated images, especially for underrepresented skin tones and rare diseases, impedes progress toward measurably fair methods. We introduce cgDDI (Controllable Generation of Diverse Dermatological Imagery), a hybrid framework that (1) synthesizes realistic healthy skin samples without disturbing other input properties, (2) maps single-sample rare lesions onto novel skin-tones and locations non-parametrically, and (3) allows for efficient parametric generation with as few as 10 training samples. The framework supports both human and automated segmentation masking, enabling scalability to datasets without pre-made lesion masks. We grow a 656-image dataset by more than 400x and validate across two datasets: biopsy-confirmed Diverse Dermatology Images (DDI) and expert-verified Fitzpatrick17k (F17k). On the DDI benchmark, we achieve malignancy classification accuracy of 86.4% under synthetic-only training and 90.9% state-of-the-art performance with real data fine-tuning, alongside leading fairness metrics. Cross-dataset experiments show +13.9% accuracy improvements on unseen F17k data despite minimal disease overlap. We openly release 266k+ synthetic images, code, and generative models to further support fairness research at https://github.com/hectorcarrion/ControllableGenDDI.