# Human-AI Agent Interaction as a Neuroplastic Training Environment

arXiv: https://arxiv.org/abs/2607.12823 · HTML: https://mlsanity.com/paper/2607.12823/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 12 of its 52 references that are in the map.
- First posted on arXiv 14 Jul 2026.

## Builds on (most cited first, 12 of 12)

- [Survey on Evaluation of LLM-based Agents](https://mlsanity.com/paper/2503.16416/) (2025)
- [The Landscape of Emerging AI Agent Architectures for Reasoning, Planning, and Tool Calling: A Survey](https://mlsanity.com/paper/2404.11584/) (2024)
- [A Practical Guide for Designing, Developing, and Deploying Production-Grade Agentic AI Workflows](https://mlsanity.com/paper/2512.08769/) (2025)
- [Agentsway -- Software Development Methodology for AI Agents-based Teams](https://mlsanity.com/paper/2510.23664/) (2025)
- [Towards Responsible and Explainable AI Agents with Consensus-Driven Reasoning](https://mlsanity.com/paper/2512.21699/) (2025)
- [Standardization of Psychiatric Diagnoses -- Role of Fine-tuned LLM Consortium and OpenAI-gpt-oss Reasoning LLM Enabled Decision Support System](https://mlsanity.com/paper/2510.25588/) (2025)
- [Proof-of-TBI -- Fine-Tuned Vision Language Model Consortium and OpenAI-o3 Reasoning LLM-Based Medical Diagnosis Support System for Mild Traumatic Brain Injury (TBI) Prediction](https://mlsanity.com/paper/2504.18671/) (2025)
- [ASTRIDE: A Security Threat Modeling Platform for Agentic-AI Applications](https://mlsanity.com/paper/2512.04785/) (2025)
- [AI Trust OS -- A Continuous Governance Framework for Autonomous AI Observability and Zero-Trust Compliance in Enterprise Environments](https://mlsanity.com/paper/2604.04749/) (2026)
- [Standardization of Neuromuscular Reflex Analysis -- Role of Fine-Tuned Vision-Language Model Consortium and OpenAI gpt-oss Reasoning LLM Enabled Decision Support System](https://mlsanity.com/paper/2508.12473/) (2025)
- [Think Before You Act -- A Neurocognitive Governance Model for Autonomous AI Agents](https://mlsanity.com/paper/2604.25684/) (2026)
- [MindGap: A Conversational AI Framework for Upstream Neuroplastic Intervention in Post-Traumatic Stress Disorder](https://mlsanity.com/paper/2605.14660/) (2026)

## Abstract (arXiv)

Interaction with AI agents has become one of the most frequent activities of everyday digital life. Whether conversing with an assistant, working with a coding copilot, or generating images, the interaction follows a common iterative loop: a request is issued, a result returned, appraised, and the request revised. We observe that this loop is a high-frequency stream of contact events -- moments at which a result meets a person and a conditioned response may fire before deliberate appraisal -- making everyday agent interaction an unrecognised neuroplastic training environment. When a result disappoints, reactive patterns of impatience, perfectionism, frustration, and self-criticism are repeatedly evoked, and under activity-dependent synaptic plasticity each uninterrupted cycle deepens the underlying pathway through long-term potentiation. Ordinary agent use may thus quietly strengthen the very patterns it provokes. We propose that the same training environment can be engaged to the opposite effect. Treating conditioned reactive patterns as physical neurone paths -- activated through a pre-cognitive feeling tone that opens a brief regulatory gap -- we develop a framework in which, at that gap, in place of the reactive re-prompt, a person performs behind-the-scenes observation: watching the neural process operate so the cascade does not complete and long-term depression weakens the path rather than potentiation strengthening it. We characterise this practice through three layers of observation and two modes of application: a user-guided mode requiring no change to existing tools, and an agent-assisted mode in which an ordinary agent is lightly configured to support observation at the gap. We illustrate the framework through generative image prompting, showing how a single frustrating session is behaviourally nearly identical whether or not it is observed, yet neurologically opposite.