# A Personalized Computational Framework for Assessing the Sufficiency of Partially Observed Data in Healthcare AI models

arXiv: https://arxiv.org/abs/2607.09165 · HTML: https://mlsanity.com/paper/2607.09165/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 5 of its 38 references that are in the map.
- First posted on arXiv 10 Jul 2026.

## Builds on (most cited first, 5 of 5)

- [A Unified Approach to Interpreting Model Predictions](https://mlsanity.com/paper/1705.07874/) (2017)
- [Integrated multimodal artificial intelligence framework for healthcare applications](https://mlsanity.com/paper/2202.12998/) (2022)
- [Confidence Intervals for Random Forests: The Jackknife and the Infinitesimal Jackknife](https://mlsanity.com/paper/1311.4555/) (2013)
- [A review of predictive uncertainty estimation with machine learning](https://mlsanity.com/paper/2209.08307/) (2022)
- [BASED-XAI: Breaking Ablation Studies Down for Explainable Artificial Intelligence](https://mlsanity.com/paper/2207.05566/) (2022)

## Abstract (arXiv)

Achieving early and timely diagnosis and treatment for disease is a major challenge. Recent applications of machine learning (ML) algorithms trained on patient data have shown promise in many different settings for predicting the patient health state. A challenge often faced when applying these ML algorithms is that at any given time, not all clinical variables (features) needed as input to perform prediction tasks are available. We define the concept of full-feature-capacity (FFC) to refer to prediction performance when such algorithms make use of all features on which they were trained. We then introduce Feature Sufficiency Analysis (FSA) - an analysis for determining whether a subset of all clinical features needed by an AI model is sufficient to achieve FFC. FSA estimates the underlying distributions of missing variables conditioned on features that are available. FSA provides a patient-specific assessment of whether the existing set of measured features achieves FFC. If yes, then there is no need to acquire further inputs and a ML-based prediction. We provide two case studies: prediction of need for postoperative prolonged ventilation in patients recovering from heart surgery; 10-year mortality prediction in an outpatient cohort. We also demonstrate that FSA also provides a clinically interpretable feature-ranking methodology based on prediction sufficiency, identifies intrinsically hard-to-predict patient populations, and has the potential to perform cost-aware optimization for clinical data acquisition. FSA provides a generic computational approach for determining whether incomplete clinical information is sufficient to support trustworthy AI-assisted clinical decision-making, thereby facilitating the prospective deployment of healthcare AI systems across diverse clinical settings.