# Cross-Modal Generative Framework for Signal Translation from Fetal-Maternal Electrocardiograms to Fetal Doppler Waveforms

arXiv: https://arxiv.org/abs/2607.08073 · HTML: https://mlsanity.com/paper/2607.08073/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 7 of its 37 references that are in the map.
- First posted on arXiv 9 Jul 2026.

## Builds on (most cited first, 7 of 7)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [WaveNet: A Generative Model for Raw Audio](https://mlsanity.com/paper/1609.03499/) (2016)
- [Multi-Scale Context Aggregation by Dilated Convolutions](https://mlsanity.com/paper/1511.07122/) (2015)
- [Pixel Recurrent Neural Networks](https://mlsanity.com/paper/1601.06759/) (2016)
- [DiffuSETS: 12-lead ECG Generation Conditioned on Clinical Text Reports and Patient-Specific Information](https://mlsanity.com/paper/2501.05932/) (2025)
- [Auto-FEDUS: Autoregressive Generative Modeling of Doppler Ultrasound Signals from Fetal Electrocardiograms](https://mlsanity.com/paper/2504.13233/) (2025)
- [Towards reconstruction of Pulsed-wave Doppler signals from Non-invasive fetal ECG](https://mlsanity.com/paper/2501.16651/) (2025)

## Abstract (arXiv)

Fetal electrocardiogram (fECG) and Doppler ultrasound provide complementary views of fetal cardiovascular function: fECG captures electrical activity while Doppler reflects mechanical hemodynamics shaped by factors such as placental resistance and vascular compliance. Understanding the recoverable and unrecoverable Doppler components through reconstruction from fECG offers insight into the relative contributions of electrical versus mechanical factors in fetal circulation, thereby informing clinical decisions. In addition, clinical evidence of maternal-fetal cardiac coupling suggests that maternal cardiovascular dynamics may also inform fetal hemodynamics. To computationally model these relationships, we propose a cross-modal generative framework combining dilated convolutions with cross-modal attention to selectively incorporate maternal ECG and self-attention to capture long-range temporal dependencies. Trained on 885 synchronized fetal/maternal ECG and Doppler envelope segments from 39 pregnancies, our model synthesizes Doppler envelopes with power spectral density mean squared error (PSD MSE) of 49.9 +/- 15.8 dB^2 (51% lower than two-channel baseline) and heart-rate error of 4.71 +/- 0.77 bpm (1.5% better than baseline; negligible relative to the 110-160 bpm physiological range). Cross-modal attention yields a 39% PSD MSE reduction over naive dual-channel concatenation, quantifying the contribution of maternal-fetal coupling. Our proposed framework advances computational modeling of the maternal-fetal cardiovascular system by enabling the synthesis of Doppler envelopes from dual-lead ECG. By analysis of both recoverable and residual Doppler components, this approach enables quantification of the purely mechanical contributions to Doppler waveforms -- those not recoverable from electrical recordings -- ultimately facilitating a more comprehensive fetal assessment.