# FUSE: FK-Steered Multi-Modal Flow Matching for Efficient Simulation-Based Posterior Estimation

arXiv: https://arxiv.org/abs/2607.05252 · HTML: https://mlsanity.com/paper/2607.05252/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Flow matching, time series and science, one of 14 directions in Diffusion models.
- Builds on 36 of its 66 references that are in the map.
- First posted on arXiv 6 Jul 2026.

## Placed in

- Diffusion models / [Flow matching, time series and science](https://mlsanity.com/diffusion/flow-matching-time-series-and-science/)

## Builds on (most cited first, 30 of 36)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Score-Based Generative Modeling through Stochastic Differential Equations](https://mlsanity.com/paper/2011.13456/) (2020)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Scalable Diffusion Models with Transformers](https://mlsanity.com/paper/2212.09748/) (2022)
- [Classifier-Free Diffusion Guidance](https://mlsanity.com/paper/2207.12598/) (2022)
- [Flow Matching for Generative Modeling](https://mlsanity.com/paper/2210.02747/) (2022)
- [Adding Conditional Control to Text-to-Image Diffusion Models](https://mlsanity.com/paper/2302.05543/) (2023)
- [Neural Discrete Representation Learning](https://mlsanity.com/paper/1711.00937/) (2017)
- [Scaling Rectified Flow Transformers for High-Resolution Image Synthesis](https://mlsanity.com/paper/2403.03206/) (2024)
- [DreamBooth: Fine Tuning Text-to-Image Diffusion Models for Subject-Driven Generation](https://mlsanity.com/paper/2208.12242/) (2022)
- [Taming Transformers for High-Resolution Image Synthesis](https://mlsanity.com/paper/2012.09841/) (2020)
- [Elucidating the Design Space of Diffusion-Based Generative Models](https://mlsanity.com/paper/2206.00364/) (2022)
- [InstructPix2Pix: Learning to Follow Image Editing Instructions](https://mlsanity.com/paper/2211.09800/) (2022)
- [Sinkhorn Distances: Lightspeed Computation of Optimal Transportation Distances](https://mlsanity.com/paper/1306.0895/) (2013)
- [DPM-Solver: A Fast ODE Solver for Diffusion Probabilistic Model Sampling in Around 10 Steps](https://mlsanity.com/paper/2206.00927/) (2022)
- [Consistency Models](https://mlsanity.com/paper/2303.01469/) (2023)
- [PixArt-α: Fast Training of Diffusion Transformer for Photorealistic Text-to-Image Synthesis](https://mlsanity.com/paper/2310.00426/) (2023)
- [Flow-GRPO: Training Flow Matching Models via Online RL](https://mlsanity.com/paper/2505.05470/) (2025)
- [Neural Spline Flows](https://mlsanity.com/paper/1906.04032/) (2019)
- [All are Worth Words: A ViT Backbone for Diffusion Models](https://mlsanity.com/paper/2209.12152/) (2022)
- [Rectified Flow: A Marginal Preserving Approach to Optimal Transport](https://mlsanity.com/paper/2209.14577/) (2022)
- [A General Framework for Inference-time Scaling and Steering of Diffusion Models](https://mlsanity.com/paper/2501.06848/) (2025)
- [Multimodal Generative Models for Scalable Weakly-Supervised Learning](https://mlsanity.com/paper/1802.05335/) (2018)
- [Variational Mixture-of-Experts Autoencoders for Multi-Modal Deep Generative Models](https://mlsanity.com/paper/1911.03393/) (2019)
- [Benchmarking Simulation-Based Inference](https://mlsanity.com/paper/2101.04653/) (2021)
- [Flow Matching for Scalable Simulation-Based Inference](https://mlsanity.com/paper/2305.17161/) (2023)
- [Generalized Multimodal ELBO](https://mlsanity.com/paper/2105.02470/) (2021)
- [Real-time gravitational-wave science with neural posterior estimation](https://mlsanity.com/paper/2106.12594/) (2021)

## Abstract (arXiv)

Simulation-Based Inference (SBI) is critical for scientific discovery, with generative models offering a promising path toward efficient inference. However, existing methods struggle with effective multimodal modeling. They often rely on brute-force fusion strategies that ignore the structural disparities between parameters and observations, thus limiting estimation fidelity. In this work, we introduce FUSE (Feynman-Kac steered mUlti-modal flow matching for efficient Simulation-based posterior Estimation). Unlike prior work, FUSE employs a dual-track architecture that preserves the distinct features of multimodal inputs while facilitating dynamic interaction. Additionally, we propose an FK-steered sampling strategy that leverages intermediate observation likelihoods to guide the generative trajectories, effectively improving the sample quality during inference. Our approach outperforms state-of-the-art baselines on standard SBI benchmarks, producing posteriors that closely match ground-truth MCMC. Furthermore, in a real-world exoplanet orbital estimation task, FUSE successfully resolves complex parameter degeneracies that challenge existing methods, highlighting its potential to accelerate complex scientific discoveries in astrophysics and beyond.