# Piecewise Dynamic Diffusion Regularization for Reconstruction of Cardiac Cine MRI

arXiv: https://arxiv.org/abs/2607.03299 · HTML: https://mlsanity.com/paper/2607.03299/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 16 of its 29 references that are in the map.
- First posted on arXiv 3 Jul 2026.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 16 of 16)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [Improved Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2102.09672/) (2021)
- [Align your Latents: High-Resolution Video Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2304.08818/) (2023)
- [Diffusion Posterior Sampling for General Noisy Inverse Problems](https://mlsanity.com/paper/2209.14687/) (2022)
- [Score-based diffusion models for accelerated MRI](https://mlsanity.com/paper/2110.05243/) (2021)
- [Robust Compressed Sensing MRI with Deep Generative Priors](https://mlsanity.com/paper/2108.01368/) (2021)
- [A Deep Cascade of Convolutional Neural Networks for Dynamic MR Image Reconstruction](https://mlsanity.com/paper/1704.02422/) (2017)
- [A Variational Perspective on Solving Inverse Problems with Diffusion Models](https://mlsanity.com/paper/2305.04391/) (2023)
- [Deep Learning Methods for Parallel Magnetic Resonance Image Reconstruction](https://mlsanity.com/paper/1904.01112/) (2019)
- [Time-Dependent Deep Image Prior for Dynamic MRI](https://mlsanity.com/paper/1910.01684/) (2019)
- [OCMR (v1.0)--Open-Access Multi-Coil k-Space Dataset for Cardiovascular Magnetic Resonance Imaging](https://mlsanity.com/paper/2008.03410/) (2020)
- [Spatiotemporal implicit neural representation for unsupervised dynamic MRI reconstruction](https://mlsanity.com/paper/2301.00127/) (2022)
- [Warped Diffusion: Solving Video Inverse Problems with Image Diffusion Models](https://mlsanity.com/paper/2410.16152/) (2024)
- [Implicit Neural Networks with Fourier-Feature Inputs for Free-breathing Cardiac MRI Reconstruction](https://mlsanity.com/paper/2305.06822/) (2023)
- [Multi-dynamic deep image prior for cardiac MRI](https://mlsanity.com/paper/2412.04639/) (2024)
- [Resolution-Robust 3D MRI Reconstruction with 2D Diffusion Priors: Diverse-Resolution Training Outperforms Interpolation](https://mlsanity.com/paper/2412.18584/) (2024)

## Abstract (arXiv)

Real-time cardiac cine MRI enables visualization of the beating heart during free breathing, but severe undersampling and motion make reconstruction highly challenging. A central challenge for reconstruction is incorporating powerful priors of cardiac anatomy while remaining computationally efficient. We propose Piecewise Dynamic Diffusion Regularization (PDDR), a reconstruction method that integrates a spatiotemporal diffusion model as a generative prior within a variational reconstruction framework for cine MRI. The model employs dedicated spatial layers to encode anatomical structure and temporal layers to capture cardiac motion learned from gated cine data. PDDR leverages the dynamic prior in a piecewise manner, enabling the efficient use of spatiotemporal diffusion models for processing of long real-time sequences. Experiments on retrospectively accelerated and prospective real-time cine MRI demonstrate that PDDR outperforms classical, unsupervised, and diffusion-based methods, delivering high-quality reconstructions with substantially reduced computation time compared to state-of-the-art baselines. These results highlight PDDR as a practical and scalable solution for free-breathing, real-time cardiac MRI. Code is available at https://github.com/MLI-lab/pddr.