# ProSAC-CT: Progressive Spectral-Anatomical Co-Guided Multi-Stage Diffusion Model for Low-Dose CT Denoising

arXiv: https://arxiv.org/abs/2607.01756 · HTML: https://mlsanity.com/paper/2607.01756/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 7 of its 40 references that are in the map.
- First posted on arXiv 2 Jul 2026.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 7 of 7)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [ResShift: Efficient Diffusion Model for Image Super-resolution by Residual Shifting](https://mlsanity.com/paper/2307.12348/) (2023)
- [Low-Dose CT with a Residual Encoder-Decoder Convolutional Neural Network (RED-CNN)](https://mlsanity.com/paper/1702.00288/) (2017)
- [MambaOut: Do We Really Need Mamba for Vision?](https://mlsanity.com/paper/2405.07992/) (2024)
- [CoreDiff: Contextual Error-Modulated Generalized Diffusion Model for Low-Dose CT Denoising and Generalization](https://mlsanity.com/paper/2304.01814/) (2023)
- [All-In-One Medical Image Restoration via Task-Adaptive Routing](https://mlsanity.com/paper/2405.19769/) (2024)

## Abstract (arXiv)

Low-dose computed tomography (LDCT) reduces radiation exposure but introduces stronger quantum noise, streak artifacts, and local texture degradation, which can obscure anatomical boundaries and weaken low-contrast structures. Diffusion models are promising for LDCT denoising by progressively recovering normal-dose CT (NDCT) images from degraded LDCT inputs, but existing methods often suffer from insufficient anatomical guidance, uncertain frequency-dependent recovery, and uniform reverse-process modeling. We propose ProSAC-CT, a progressive spectral-anatomical co-guided multi-stage diffusion model for image-domain LDCT denoising. ProSAC-CT integrates an anatomical-prior-guided conditioning (APGC) module, a residual frequency-domain decoupling stage (RFDDS), and a time-step-decoupling denoising decoder (TD3). APGC extracts LDCT-derived structural guidance, RFDDS enhances frequency-aware representations, and TD3 assigns them to different reverse-diffusion stages for anatomical stabilization, boundary refinement, and fine-detail recovery. Experiments on four LDCT degradation benchmarks show that ProSAC-CT improves image fidelity, structural similarity, perceptual quality, and information preservation over representative methods while better preserving boundary-sensitive anatomical details. Downstream anatomical-region classification on Mayo-2020 further indicates that ProSAC-CT retains task-relevant anatomical information, supporting its practical use for low-dose CT denoising.