# HistoSeg++: Delving deeper with attention and multiscale feature fusion for biomarker segmentation

arXiv: https://arxiv.org/abs/2607.01675 · HTML: https://mlsanity.com/paper/2607.01675/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 10 of its 19 references that are in the map.
- First posted on arXiv 2 Jul 2026.

## Builds on (most cited first, 10 of 10)

- [Fully Convolutional Networks for Semantic Segmentation](https://mlsanity.com/paper/1411.4038/) (2014)
- [DeepLab: Semantic Image Segmentation with Deep Convolutional Nets, Atrous Convolution, and Fully Connected CRFs](https://mlsanity.com/paper/1606.00915/) (2016)
- [TransUNet: Transformers Make Strong Encoders for Medical Image Segmentation](https://mlsanity.com/paper/2102.04306/) (2021)
- [Attention U-Net: Learning Where to Look for the Pancreas](https://mlsanity.com/paper/1804.03999/) (2018)
- [U2-Net: Going Deeper with Nested U-Structure for Salient Object Detection](https://mlsanity.com/paper/2005.09007/) (2020)
- [HoVer-Net: Simultaneous Segmentation and Classification of Nuclei in Multi-Tissue Histology Images](https://mlsanity.com/paper/1812.06499/) (2018)
- [UNet 3+: A Full-Scale Connected UNet for Medical Image Segmentation](https://mlsanity.com/paper/2004.08790/) (2020)
- [Amulet: Aggregating Multi-level Convolutional Features for Salient Object Detection](https://mlsanity.com/paper/1708.02001/) (2017)
- [HistoSeg : Quick attention with multi-loss function for multi-structure segmentation in digital histology images](https://mlsanity.com/paper/2209.00729/) (2022)
- [MA-Unet: An improved version of Unet based on multi-scale and attention mechanism for medical image segmentation](https://mlsanity.com/paper/2012.10952/) (2020)

## Abstract (arXiv)

Segmentation of biomarkers in medical images is frequently viewed as a first step towards medical image analysis in any bioinformatics or biomedical application. Despite progress, existing methods still struggle to capture information at multiple scales and to perform upsampling effectively across different datasets. These shortcomings often result in suboptimal generalization capabilities. Recently, architectures belonging to the Nested-UNet family excel in capturing multiscale contextual information and upsample them effectively. In this work, We propose a novel Nested-UNet architecture that effectively captures multi-scale contextual information. It includes inner and outer attention units to enhance focus during upsampling, along with channel-wise feature recalibration using squeeze-and-excitation modules, leading to improved segmentation performance. Additionally, the architecture integrates an edge-aware loss to emphasize boundary accuracy by assigning greater importance to edge regions. Tested extensively on three publicly available benchmark datasets. Our method demonstrates a generalization performance superior to existing Nested-UNet methods. Code: https://github.com/saadwazir/histosegplusplus