# Plug-and-Play Volumetric Reconstruction for Compressive Sensing Light-Sheet Microscopy

arXiv: https://arxiv.org/abs/2607.01654 · HTML: https://mlsanity.com/paper/2607.01654/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 12 of its 61 references that are in the map.
- First posted on arXiv 2 Jul 2026.

## Builds on (most cited first, 12 of 12)

- [Beyond a Gaussian Denoiser: Residual Learning of Deep CNN for Image Denoising](https://mlsanity.com/paper/1608.03981/) (2016)
- [FFDNet: Toward a Fast and Flexible Solution for CNN based Image Denoising](https://mlsanity.com/paper/1710.04026/) (2017)
- [Plug-and-Play Image Restoration with Deep Denoiser Prior](https://mlsanity.com/paper/2008.13751/) (2020)
- [Plug-and-Play ADMM for Image Restoration: Fixed Point Convergence and Applications](https://mlsanity.com/paper/1605.01710/) (2016)
- [Plug-and-Play Methods Provably Converge with Properly Trained Denoisers](https://mlsanity.com/paper/1905.05406/) (2019)
- [Global Convergence of ADMM in Nonconvex Nonsmooth Optimization](https://mlsanity.com/paper/1511.06324/) (2015)
- [Proximal Denoiser for Convergent Plug-and-Play Optimization with Nonconvex Regularization](https://mlsanity.com/paper/2201.13256/) (2022)
- [Tuning-free Plug-and-Play Proximal Algorithm for Inverse Imaging Problems](https://mlsanity.com/paper/2002.09611/) (2020)
- [Prune2Drive: A Plug-and-Play Framework for Accelerating Vision-Language Models in Autonomous Driving](https://mlsanity.com/paper/2508.13305/) (2025)
- [A Plug-and-Play Priors Framework for Hyperspectral Unmixing](https://mlsanity.com/paper/2012.13074/) (2020)
- [Prior Mismatch and Adaptation in PnP-ADMM with a Nonconvex Convergence Analysis](https://mlsanity.com/paper/2310.00133/) (2023)
- [Limited-angle x-ray nano-tomography with machine-learning enabled iterative reconstruction engine](https://mlsanity.com/paper/2503.19248/) (2025)

## Abstract (arXiv)

We investigate volumetric reconstruction for compressive sensing light-sheet microscopy (CS-LSM), where fast volumetric imaging is achieved by encoding multiple axial planes into each camera exposure. To recover the underlying volume from highly multiplexed measurements, we propose a plug-and-play (PnP) framework that flexibly incorporates any user-specified denoiser into the reconstruction process. Building on a slice-based formulation, we further introduce an axial-coupled model that exploits correlations between adjacent slices to improve volumetric continuity. For efficient computation, we derive a Woodbury-based update for the data-consistency step in both the slice-based and axial-coupled formulations, and employ a Gauss-Seidel sweep for the denoising step in the axial-coupled model. Under a weakly convex regularization assumption, we establish subsequential convergence of the proposed algorithm. Experiments on synthetic and real zebrafish-heart data demonstrate that the proposed framework successfully recovers cellular structures from compressed measurements, and provide practical insights into the comparative performance of commonly used denoisers within the PnP framework under the CS-LSM setup.