# On the Utility and Factual Reliability of Pruned Mixture-of-Experts Models in the Biomedical Domain

arXiv: https://arxiv.org/abs/2607.01444 · HTML: https://mlsanity.com/paper/2607.01444/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Medical and biomedical MoE, one of 12 directions in Mixture-of-experts.
- Builds on 40 of its 59 references that are in the map.
- First posted on arXiv 1 Jul 2026.

## Placed in

- Mixture-of-experts / [Medical and biomedical MoE](https://mlsanity.com/moe/medical-and-biomedical-moe/)
- Efficient LLM inference and serving / [Diffusion LLM and MoE inference](https://mlsanity.com/inference/diffusion-llm-and-moe-inference/)

## Builds on (most cited first, 30 of 40)

- [Training Verifiers to Solve Math Word Problems](https://mlsanity.com/paper/2110.14168/) (2021)
- [Judging LLM-as-a-Judge with MT-Bench and Chatbot Arena](https://mlsanity.com/paper/2306.05685/) (2023)
- [Evaluating Large Language Models Trained on Code](https://mlsanity.com/paper/2107.03374/) (2021)
- [Measuring Massive Multitask Language Understanding](https://mlsanity.com/paper/2009.03300/) (2020)
- [Efficient Memory Management for Large Language Model Serving with PagedAttention](https://mlsanity.com/paper/2309.06180/) (2023)
- [BERTScore: Evaluating Text Generation with BERT](https://mlsanity.com/paper/1904.09675/) (2019)
- [FlashAttention-2: Faster Attention with Better Parallelism and Work Partitioning](https://mlsanity.com/paper/2307.08691/) (2023)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)
- [GLaM: Efficient Scaling of Language Models with Mixture-of-Experts](https://mlsanity.com/paper/2112.06905/) (2021)
- [Not All Experts are Equal: Efficient Expert Pruning and Skipping for Mixture-of-Experts Large Language Models](https://mlsanity.com/paper/2402.14800/) (2024)
- [Merge, Then Compress: Demystify Efficient SMoE with Hints from Its Routing Policy](https://mlsanity.com/paper/2310.01334/) (2023)
- [Multi-XScience: A Large-scale Dataset for Extreme Multi-document Summarization of Scientific Articles](https://mlsanity.com/paper/2010.14235/) (2020)
- [Scalable and Efficient MoE Training for Multitask Multilingual Models](https://mlsanity.com/paper/2109.10465/) (2021)
- [Task-Specific Expert Pruning for Sparse Mixture-of-Experts](https://mlsanity.com/paper/2206.00277/) (2022)
- [Decoding Compressed Trust: Scrutinizing the Trustworthiness of Efficient LLMs Under Compression](https://mlsanity.com/paper/2403.15447/) (2024)
- [MoE-I2: Compressing Mixture of Experts Models through Inter-Expert Pruning and Intra-Expert Low-Rank Decomposition](https://mlsanity.com/paper/2411.01016/) (2024)
- [REAP the Experts: Why Pruning Prevails for One-Shot MoE compression](https://mlsanity.com/paper/2510.13999/) (2025)
- [SEER-MoE: Sparse Expert Efficiency through Regularization for Mixture-of-Experts](https://mlsanity.com/paper/2404.05089/) (2024)
- [Merging Experts into One: Improving Computational Efficiency of Mixture of Experts](https://mlsanity.com/paper/2310.09832/) (2023)
- [Diversifying the Expert Knowledge for Task-Agnostic Pruning in Sparse Mixture-of-Experts](https://mlsanity.com/paper/2407.09590/) (2024)
- [Retraining-Free Merging of Sparse MoE via Hierarchical Clustering](https://mlsanity.com/paper/2410.08589/) (2024)
- [MoEQuant: Enhancing Quantization for Mixture-of-Experts Large Language Models via Expert-Balanced Sampling and Affinity Guidance](https://mlsanity.com/paper/2505.03804/) (2025)
- [DiEP: Adaptive Mixture-of-Experts Compression through Differentiable Expert Pruning](https://mlsanity.com/paper/2509.16105/) (2025)
- [Dropping Experts, Recombining Neurons: Retraining-Free Pruning for Sparse Mixture-of-Experts LLMs](https://mlsanity.com/paper/2509.10377/) (2025)
- [Mix Data or Merge Models? Balancing the Helpfulness, Honesty, and Harmlessness of Large Language Model via Model Merging](https://mlsanity.com/paper/2502.06876/) (2025)
- [Finding Fantastic Experts in MoEs: A Unified Study for Expert Dropping Strategies and Observations](https://mlsanity.com/paper/2504.05586/) (2025)
- [Investigating Hallucinations in Pruned Large Language Models for Abstractive Summarization](https://mlsanity.com/paper/2311.09335/) (2023)
- [Multi-News+: Cost-efficient Dataset Cleansing via LLM-based Data Annotation](https://mlsanity.com/paper/2404.09682/) (2024)

## Built on by (most cited first, 1 of 1)

- [Half the Experts, All the Code: One-Shot Domain Pruning of Mixture-of-Experts LLMs for Coding](https://mlsanity.com/paper/2607.16721/) (2026)

## Abstract (arXiv)

Mixture-of-Experts (MoE) models offer inference speedups via selective activation but impose substantial memory requirements because the whole network must remain loaded. Structured expert pruning is a practical approach for reducing deployment costs in resource-constrained settings. However, prior studies primarily evaluate benchmark utility, leaving the effect of pruning on factual reliability underexplored, particularly in high-stakes domains such as biomedicine. In this paper, we investigate how domain-specific expert pruning affects both utility and reliability. We assess four MoE models, six pruning methods, and multiple pruning ratios across generation and classification tasks under in-domain (biomedical) and cross-domain settings. Results reveal that moderate pruning preserves in-domain utility without immediate reliability decline, although hallucination risks increase at extreme pruning ratios. When shifting to the general domain, both utility and reliability degrade rapidly. These findings indicate that safe compression depends heavily on the task and domain. Evaluating pruned MoE models solely on utility is inadequate for high-stakes deployment without reliability assessment.