# Agentic evolution of physically constrained foundation models

arXiv: https://arxiv.org/abs/2606.25532 · HTML: https://mlsanity.com/paper/2606.25532/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Web, search, and research agents, one of 16 directions in LLM agents and tool use.
- Builds on 21 of its 43 references that are in the map.
- First posted on arXiv 24 Jun 2026.

## Placed in

- LLM agents and tool use / [Web, search, and research agents](https://mlsanity.com/agents/web-search-and-research-agents/)
- Mixture-of-experts / [MoE in reinforcement learning and robotics](https://mlsanity.com/moe/moe-in-reinforcement-learning-and-robotics/)

## Builds on (most cited first, 21 of 21)

- [GPTQ: Accurate Post-Training Quantization for Generative Pre-trained Transformers](https://mlsanity.com/paper/2210.17323/) (2022)
- [Competition-Level Code Generation with AlphaCode](https://mlsanity.com/paper/2203.07814/) (2022)
- [SmoothQuant: Accurate and Efficient Post-Training Quantization for Large Language Models](https://mlsanity.com/paper/2211.10438/) (2022)
- [AWQ: Activation-aware Weight Quantization for LLM Compression and Acceleration](https://mlsanity.com/paper/2306.00978/) (2023)
- [QuaRot: Outlier-Free 4-Bit Inference in Rotated LLMs](https://mlsanity.com/paper/2404.00456/) (2024)
- [KVQuant: Towards 10 Million Context Length LLM Inference with KV Cache Quantization](https://mlsanity.com/paper/2401.18079/) (2024)
- [Eureka: Human-Level Reward Design via Coding Large Language Models](https://mlsanity.com/paper/2310.12931/) (2023)
- [OmniQuant: Omnidirectionally Calibrated Quantization for Large Language Models](https://mlsanity.com/paper/2308.13137/) (2023)
- [Atom: Low-bit Quantization for Efficient and Accurate LLM Serving](https://mlsanity.com/paper/2310.19102/) (2023)
- [Towards End-to-End Automation of AI Research](https://mlsanity.com/paper/2606.15497/) (2026)
- [A Survey on Evolutionary Neural Architecture Search](https://mlsanity.com/paper/2008.10937/) (2020)
- [Empowering Biomedical Discovery with AI Agents](https://mlsanity.com/paper/2404.02831/) (2024)
- [Evolutionary Computation in the Era of Large Language Model: Survey and Roadmap](https://mlsanity.com/paper/2401.10034/) (2024)
- [Evaluating Quantized Large Language Models](https://mlsanity.com/paper/2402.18158/) (2024)
- [SliM-LLM: Salience-Driven Mixed-Precision Quantization for Large Language Models](https://mlsanity.com/paper/2405.14917/) (2024)
- [Multi-objective Evolution of Heuristic Using Large Language Model](https://mlsanity.com/paper/2409.16867/) (2024)
- [Autonomous LLM-driven research from data to human-verifiable research papers](https://mlsanity.com/paper/2404.17605/) (2024)
- [Jet-Nemotron: Efficient Language Model with Post Neural Architecture Search](https://mlsanity.com/paper/2508.15884/) (2025)
- [SAC-KG: Exploiting Large Language Models as Skilled Automatic Constructors for Domain Knowledge Graphs](https://mlsanity.com/paper/2410.02811/) (2024)
- [MxMoE: Mixed-precision Quantization for MoE with Accuracy and Performance Co-Design](https://mlsanity.com/paper/2505.05799/) (2025)
- [EvoPress: Accurate Dynamic Model Compression via Evolutionary Search](https://mlsanity.com/paper/2410.14649/) (2024)

## Abstract (arXiv)

Artificial intelligence increasingly drives automated scientific discovery, yet contemporary generalist agents lack physical grounding, frequently hallucinating hardware-incompatible designs. Here, we present a physically grounded, multi-agent discovery engine that autonomously architects hardware-compliant computing systems. Anchored by an Evolutionary Knowledge Graph structuring past scientific innovations, the framework extracts an "algorithmic Chain-of-Thought" to transform blind stochastic search into directed structural evolution. Applied to the extreme testbed of foundation model deployment, the engine evolved two hardware-aware compression methodologies surpassing human-engineered heuristics: Q-Enhance mitigates long-context accuracy loss in dense models, and MoE-Salient-AQ outperforms state-of-the-art manual sparse Mixture-of-Experts designs by 3.7% at sub-3-bit regimes. Utilizing a bandwidth-efficient Sensitivity Profile, we successfully deployed a massive 235-billion-parameter model onto a constrained dual-A100 server, reducing memory requirements by 75% with a marginal 0.64% accuracy degradation. By transforming unconstrained combinatorial search into knowledge-driven autonomy, this establishes a scalable hardware-software co-design paradigm for machine-driven discovery within strict physical boundaries.