# Dementia-Agents: A Multi-Modal Multi-Agent System for Dementia Staging and Phenotyping

arXiv: https://arxiv.org/abs/2606.21168 · HTML: https://mlsanity.com/paper/2606.21168/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical and scientific domain agents, one of 16 directions in LLM agents and tool use.
- Builds on 11 of its 25 references that are in the map.
- First posted on arXiv 19 Jun 2026.

## Placed in

- LLM agents and tool use / [Medical and scientific domain agents](https://mlsanity.com/agents/medical-and-scientific-domain-agents/)

## Builds on (most cited first, 11 of 11)

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- [InternVL3.5: Advancing Open-Source Multimodal Models in Versatility, Reasoning, and Efficiency](https://mlsanity.com/paper/2508.18265/) (2025)
- [LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Day](https://mlsanity.com/paper/2306.00890/) (2023)
- [Qwen3 Embedding: Advancing Text Embedding and Reranking Through Foundation Models](https://mlsanity.com/paper/2506.05176/) (2025)
- [MedAgents: Large Language Models as Collaborators for Zero-shot Medical Reasoning](https://mlsanity.com/paper/2311.10537/) (2023)
- [Qwen3-VL-Embedding and Qwen3-VL-Reranker: A Unified Framework for State-of-the-Art Multimodal Retrieval and Ranking](https://mlsanity.com/paper/2601.04720/) (2026)
- [Hulu-Med: A Transparent Generalist Model towards Holistic Medical Vision-Language Understanding](https://mlsanity.com/paper/2510.08668/) (2025)
- [ADAgent: LLM Agent for Alzheimer's Disease Analysis with Collaborative Coordinator](https://mlsanity.com/paper/2506.11150/) (2025)
- [DiaMond: Dementia Diagnosis with Multi-Modal Vision Transformers Using MRI and PET](https://mlsanity.com/paper/2410.23219/) (2024)
- [Dementia-R1: Reinforced Pretraining and Reasoning from Unstructured Clinical Notes for Real-World Dementia Prognosis](https://mlsanity.com/paper/2601.03018/) (2026)
- [Data-Efficient Fine-Tuning of Vision-Language Models for Diagnosis of Alzheimer's Disease](https://mlsanity.com/paper/2509.07613/) (2025)

## Abstract (arXiv)

Dementia diagnosis requires integrating multi-modal clinical assessments from diverse informants and clinicians under incomplete and heterogeneous data conditions. Yet most AI-driven approaches remain Alzheimer's disease (AD)-centric, framing the problem as binary AD detection or three-stage AD progression modeling within well-curated research settings. This pathology-driven paradigm overlooks the broader, syndrome-level nature of dementia, which spans multiple stages, phenotypes, and etiologies. In this paper, we propose Dementia-Agents, a clinically aligned multi-agent framework for real-world dementia staging and phenotyping. The framework follows a three-step workflow: (1) a data agent translates structured clinical records into semantically faithful textual representations that preserve missing-data signals and routes them to domain-aligned experts; (2) five fine-tuned expert agents generate domain-level predictions; and (3) a coordinator agent performs probabilistic aggregation to produce final staging and phenotyping decisions. We develop and evaluate Dementia-Agents on a real-world clinical cohort of 1,066 patients from two cognitive neurology services. Compared with monolithic multi-modal large language models (MLLMs) and prior medical multi-agent systems, our approach achieves consistent improvements in diagnostic performance for real-world syndrome-level dementia staging and phenotyping, while preserving domain-level interpretability.