# BioInsight: Multi-Agent Orchestration for Interactive Biomedical Knowledge Discovery

arXiv: https://arxiv.org/abs/2606.20997 · HTML: https://mlsanity.com/paper/2606.20997/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 21 of its 43 references that are in the map.
- First posted on arXiv 19 Jun 2026.

## Builds on (most cited first, 21 of 21)

- [ReAct: Synergizing Reasoning and Acting in Language Models](https://mlsanity.com/paper/2210.03629/) (2022)
- [AutoGen: Enabling Next-Gen LLM Applications via Multi-Agent Conversation](https://mlsanity.com/paper/2308.08155/) (2023)
- [Self-RAG: Learning to Retrieve, Generate, and Critique through Self-Reflection](https://mlsanity.com/paper/2310.11511/) (2023)
- [Search-R1: Training LLMs to Reason and Leverage Search Engines with Reinforcement Learning](https://mlsanity.com/paper/2503.09516/) (2025)
- [WebThinker: Empowering Large Reasoning Models with Deep Research Capability](https://mlsanity.com/paper/2504.21776/) (2025)
- [Beyond Ten Turns: Unlocking Long-Horizon Agentic Search with Large-Scale Asynchronous RL](https://mlsanity.com/paper/2508.07976/) (2025)
- [Empowering Biomedical Discovery with AI Agents](https://mlsanity.com/paper/2404.02831/) (2024)
- [DR Tulu: Reinforcement Learning with Evolving Rubrics for Deep Research](https://mlsanity.com/paper/2511.19399/) (2025)
- [WebExplorer: Explore and Evolve for Training Long-Horizon Web Agents](https://mlsanity.com/paper/2509.06501/) (2025)
- [Deep Research: A Survey of Autonomous Research Agents](https://mlsanity.com/paper/2508.12752/) (2025)
- [METAL: A Multi-Agent Framework for Chart Generation with Test-Time Scaling](https://mlsanity.com/paper/2502.17651/) (2025)
- [Large-scale analysis of disease pathways in the human interactome](https://mlsanity.com/paper/1712.00843/) (2017)
- [TinyScientist: An Interactive, Extensible, and Controllable Framework for Building Research Agents](https://mlsanity.com/paper/2510.06579/) (2025)
- [Generative UI: LLMs are Effective UI Generators](https://mlsanity.com/paper/2604.09577/) (2026)
- [OSExpert: Computer-Use Agents Learning Professional Skills via Exploration](https://mlsanity.com/paper/2603.07978/) (2026)
- [EchoFoley: Event-Centric Hierarchical Control for Video Grounded Creative Sound Generation](https://mlsanity.com/paper/2512.24731/) (2025)
- [BioMedSearch: A Multi-Source Biomedical Retrieval Framework Based on LLMs](https://mlsanity.com/paper/2510.13926/) (2025)
- [PEARL: Self-Evolving Assistant for Time Management with Reinforcement Learning](https://mlsanity.com/paper/2601.11957/) (2026)
- [Leveraging Generative AI for Clinical Evidence Summarization Needs to Ensure Trustworthiness](https://mlsanity.com/paper/2311.11211/) (2023)
- [PaperVoyager : Building Interactive Web with Visual Language Models](https://mlsanity.com/paper/2603.22999/) (2026)
- [Towards Trustworthy Report Generation: A Deep Research Agent with Progressive Confidence Estimation and Calibration](https://mlsanity.com/paper/2604.05952/) (2026)

## Built on by (most cited first, 1 of 1)

- [Evaluating Agentic Bioinformatics through Function, Evidence, and Validation](https://mlsanity.com/paper/2607.27556/) (2026)

## Abstract (arXiv)

Biomedical deep-research systems increasingly retrieve and synthesize scientific evidence, but their outputs typically collapse heterogeneous evidence into static text, making provenance difficult to inspect and reuse. We formulate evidence-centered biomedical knowledge discovery, where disease-associated protein signals are transformed into a structured evidence state connecting proteins, pathways, publications, interactions, claims, and uncertainty. We introduce BioInsight, a provenance-preserving multi-agent orchestration framework built around typed artifact contracts and an independent Search Agent that decouples evidence acquisition from downstream mechanistic reasoning, supporting both the citation-grounded report and an interactive evidence workspace, without independently regenerating evidence for visualization. We evaluate BioInsight on standardized biomedical QA, challenging protein-function reasoning, and end-to-end biomedical evidence synthesis. The results demonstrate that BioInsight achieves better traceability and ranking performance than standard search-augmented baselines, and suggest that biomedical AI systems should move toward provenance-preserving, interactive evidence artifacts.