# Single-Stage Hierarchical Rectification for Weakly Supervised Histopathology Segmentation

arXiv: https://arxiv.org/abs/2606.20250 · HTML: https://mlsanity.com/paper/2606.20250/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 8 of its 19 references that are in the map.
- First posted on arXiv 18 Jun 2026.

## Builds on (most cited first, 8 of 8)

- [Learning Deep Features for Discriminative Localization](https://mlsanity.com/paper/1512.04150/) (2015)
- [Wider or Deeper: Revisiting the ResNet Model for Visual Recognition](https://mlsanity.com/paper/1611.10080/) (2016)
- [Deep neural network models for computational histopathology: A survey](https://mlsanity.com/paper/1912.12378/) (2019)
- [Multi-Layer Pseudo-Supervision for Histopathology Tissue Semantic Segmentation using Patch-level Classification Labels](https://mlsanity.com/paper/2110.08048/) (2021)
- [NuCLS: A scalable crowdsourcing, deep learning approach and dataset for nucleus classification, localization and segmentation](https://mlsanity.com/paper/2102.09099/) (2021)
- [Towards Label-efficient Automatic Diagnosis and Analysis: A Comprehensive Survey of Advanced Deep Learning-based Weakly-supervised, Semi-supervised and Self-supervised Techniques in Histopathological Image Analysis](https://mlsanity.com/paper/2208.08789/) (2022)
- [DuPL: Dual Student with Trustworthy Progressive Learning for Robust Weakly Supervised Semantic Segmentation](https://mlsanity.com/paper/2403.11184/) (2024)
- [Prototype-Based Image Prompting for Weakly Supervised Histopathological Image Segmentation](https://mlsanity.com/paper/2503.12068/) (2025)

## Abstract (arXiv)

Existing weakly supervised semantic segmentation (WSSS) methods in computational pathology rely on a multi-stage paradigm: class activation map (CAM) generation, offline pseudo-mask refinement, and fully supervised retraining. While established, this decoupled approach presents fundamental limitations. The multi-stage process not only incurs high computational training costs but also suffers from error propagation: local texture biases in shallow CNN layers generate false-positive artifacts that subsequent refinement steps often fail to correct. To address these persistent challenges through a simple yet highly effective approach, we propose the Single-Stage Hierarchical Rectification (SSHR) framework. Rather than passively refining CAMs post-hoc, our method proactively purifies intermediate feature representations during the forward pass. We introduce a Hierarchical Feature Rectification Module (HFRM) that utilizes deep global semantic context to filter out local anomalies in shallow layers. This mechanism generates high-fidelity activation maps directly within a single training loop. Experiments on the LUAD-HistoSeg and BCSS datasets demonstrate that SSHR outperforms state-of-the-art multi-stage methods. Furthermore, SSHR reduces training duration by 2 to 5 times. This efficiency minimizes computational overhead and accelerates clinical translation for large-scale histopathology workflows. The code is available at: https://github.com/trongduc-nguyen/SSHR