# PSyGenTAB: A Privacy-Preserving Framework for Synthetic Clinical Tabular Data Generation via Constrained Optimization

arXiv: https://arxiv.org/abs/2606.18518 · HTML: https://mlsanity.com/paper/2606.18518/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 22 of its 64 references that are in the map.
- First posted on arXiv 16 Jun 2026.

## Builds on (most cited first, 22 of 22)

- [Deep Learning with Differential Privacy](https://mlsanity.com/paper/1607.00133/) (2016)
- [Membership Inference Attacks against Machine Learning Models](https://mlsanity.com/paper/1610.05820/) (2016)
- [Deep Leakage from Gradients](https://mlsanity.com/paper/1906.08935/) (2019)
- [Membership Inference Attacks From First Principles](https://mlsanity.com/paper/2112.03570/) (2021)
- [Modeling Tabular data using Conditional GAN](https://mlsanity.com/paper/1907.00503/) (2019)
- [The Future of Digital Health with Federated Learning](https://mlsanity.com/paper/2003.08119/) (2020)
- [TabDDPM: Modelling Tabular Data with Diffusion Models](https://mlsanity.com/paper/2209.15421/) (2022)
- [Language Models are Realistic Tabular Data Generators](https://mlsanity.com/paper/2210.06280/) (2022)
- [Mixed-Type Tabular Data Synthesis with Score-based Diffusion in Latent Space](https://mlsanity.com/paper/2310.09656/) (2023)
- [Data Synthesis based on Generative Adversarial Networks](https://mlsanity.com/paper/1806.03384/) (2018)
- [REaLTabFormer: Generating Realistic Relational and Tabular Data using Transformers](https://mlsanity.com/paper/2302.02041/) (2023)
- [Synthesizing Tabular Data using Generative Adversarial Networks](https://mlsanity.com/paper/1811.11264/) (2018)
- [CTAB-GAN+: Enhancing Tabular Data Synthesis](https://mlsanity.com/paper/2204.00401/) (2022)
- [Synthetic Data -- what, why and how?](https://mlsanity.com/paper/2205.03257/) (2022)
- [Two-Player Games for Efficient Non-Convex Constrained Optimization](https://mlsanity.com/paper/1804.06500/) (2018)
- [TabSynDex: A Universal Metric for Robust Evaluation of Synthetic Tabular Data](https://mlsanity.com/paper/2207.05295/) (2022)
- [SynthEval: A Framework for Detailed Utility and Privacy Evaluation of Tabular Synthetic Data](https://mlsanity.com/paper/2404.15821/) (2024)
- [Stochastic Inexact Augmented Lagrangian Method for Nonconvex Expectation Constrained Optimization](https://mlsanity.com/paper/2212.09513/) (2022)
- [Learning Constrained Optimization with Deep Augmented Lagrangian Methods](https://mlsanity.com/paper/2403.03454/) (2024)
- [The DCR Delusion: Measuring the Privacy Risk of Synthetic Data](https://mlsanity.com/paper/2505.01524/) (2025)
- [SynLLM: A Comparative Analysis of Large Language Models for Medical Tabular Synthetic Data Generation via Prompt Engineering](https://mlsanity.com/paper/2508.08529/) (2025)
- [Democratizing Tabular Data Access with an Openunicodex2013Source Syntheticunicodex2013Data SDK](https://mlsanity.com/paper/2508.00718/) (2025)

## Abstract (arXiv)

The development of medical AI is constrained by limited access to high-quality clinical data due to institutional silos and strict privacy regulations such as HIPAA and GDPR. Synthetic data generation offers a potential solution, but existing methods lack principled mechanisms to explicitly manage the privacy-utility trade-off, often degrading clinically meaningful patterns or risking patient re-identification. We present PSyGenTAB, a privacy-preserving generative framework that formulates synthetic healthcare data generation as a constrained optimization problem solved using the Augmented Lagrangian Method. By embedding configurable privacy constraints directly into model training, PSyGenTAB enforces minimum privacy thresholds while maximizing clinical data utility. Across multiple clinically motivated benchmarks, PSyGenTAB preserves inter-feature clinical relationships and minority-class diagnostic patterns essential for reliable health AI. Downstream evaluation using Train-on-Synthetic, Test-on-Real and Train-on-Real, Test-on-Synthetic protocols shows that models trained on synthetic data achieve performance comparable to those trained on real patient records. Privacy auditing further demonstrates reduced exact record reproduction and strong resilience to membership inference attacks. These results establish PSyGenTAB as a principled framework for balancing privacy protection and clinical utility in synthetic healthcare data, supporting secure cross-institutional AI development.