# LabOSBench: Benchmarking Computer Use Agents for Scientific Instrument Control

arXiv: https://arxiv.org/abs/2606.16802 · HTML: https://mlsanity.com/paper/2606.16802/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Web, search, and research agents, one of 16 directions in LLM agents and tool use.
- Builds on 27 of its 36 references that are in the map.
- First posted on arXiv 15 Jun 2026.

## Placed in

- LLM agents and tool use / [Web, search, and research agents](https://mlsanity.com/agents/web-search-and-research-agents/)

## Builds on (most cited first, 27 of 27)

- [ReAct: Synergizing Reasoning and Acting in Language Models](https://mlsanity.com/paper/2210.03629/) (2022)
- [Qwen3-VL Technical Report](https://mlsanity.com/paper/2511.21631/) (2025)
- [WebArena: A Realistic Web Environment for Building Autonomous Agents](https://mlsanity.com/paper/2307.13854/) (2023)
- [Mind2Web: Towards a Generalist Agent for the Web](https://mlsanity.com/paper/2306.06070/) (2023)
- [OSWorld: Benchmarking Multimodal Agents for Open-Ended Tasks in Real Computer Environments](https://mlsanity.com/paper/2404.07972/) (2024)
- [The AI Scientist: Towards Fully Automated Open-Ended Scientific Discovery](https://mlsanity.com/paper/2408.06292/) (2024)
- [UI-TARS: Pioneering Automated GUI Interaction with Native Agents](https://mlsanity.com/paper/2501.12326/) (2025)
- [GPT-4V(ision) is a Generalist Web Agent, if Grounded](https://mlsanity.com/paper/2401.01614/) (2024)
- [Kimi K2.5: Visual Agentic Intelligence](https://mlsanity.com/paper/2602.02276/) (2026)
- [AndroidWorld: A Dynamic Benchmarking Environment for Autonomous Agents](https://mlsanity.com/paper/2405.14573/) (2024)
- [WebVoyager: Building an End-to-End Web Agent with Large Multimodal Models](https://mlsanity.com/paper/2401.13919/) (2024)
- [MLAgentBench: Evaluating Language Agents on Machine Learning Experimentation](https://mlsanity.com/paper/2310.03302/) (2023)
- [ScienceWorld: Is your Agent Smarter than a 5th Grader?](https://mlsanity.com/paper/2203.07540/) (2022)
- [ScreenSpot-Pro: GUI Grounding for Professional High-Resolution Computer Use](https://mlsanity.com/paper/2504.07981/) (2025)
- [Windows Agent Arena: Evaluating Multi-Modal OS Agents at Scale](https://mlsanity.com/paper/2409.08264/) (2024)
- [OmniParser for Pure Vision Based GUI Agent](https://mlsanity.com/paper/2408.00203/) (2024)
- [AndroidLab: Training and Systematic Benchmarking of Android Autonomous Agents](https://mlsanity.com/paper/2410.24024/) (2024)
- [DISCOVERYWORLD: A Virtual Environment for Developing and Evaluating Automated Scientific Discovery Agents](https://mlsanity.com/paper/2406.06769/) (2024)
- [ScaleCUA: Scaling Open-Source Computer Use Agents with Cross-Platform Data](https://mlsanity.com/paper/2509.15221/) (2025)
- [EvoCUA: Evolving Computer Use Agents via Learning from Scalable Synthetic Experience](https://mlsanity.com/paper/2601.15876/) (2026)
- [ScienceBoard: Evaluating Multimodal Autonomous Agents in Realistic Scientific Workflows](https://mlsanity.com/paper/2505.19897/) (2025)
- [MobileRL: Online Agentic Reinforcement Learning for Mobile GUI Agents](https://mlsanity.com/paper/2509.18119/) (2025)
- [macOSWorld: A Multilingual Interactive Benchmark for GUI Agents](https://mlsanity.com/paper/2506.04135/) (2025)
- [OSUniverse: Benchmark for Multimodal GUI-navigation AI Agents](https://mlsanity.com/paper/2505.03570/) (2025)
- [OS-Themis: A Scalable Critic Framework for Generalist GUI Rewards](https://mlsanity.com/paper/2603.19191/) (2026)
- [OS-Oracle: A Comprehensive Framework for Cross-Platform GUI Critic Models](https://mlsanity.com/paper/2512.16295/) (2025)
- [Owl-AuraID 1.0: An Intelligent System for Autonomous Scientific Instrumentation and Scientific Data Analysis](https://mlsanity.com/paper/2603.29828/) (2026)

## Built on by (most cited first, 1 of 1)

- [How Benchmarks Mis-Score Computer-Use Agents](https://mlsanity.com/paper/2607.28367/) (2026)

## Abstract (arXiv)

Current computer-use benchmarks primarily focus on software operation tasks in virtualized systems, whereas scientific instrumentation scenarios require coordinated control over complex interfaces, and feedback-driven parameter adjustment. However, directly evaluating agents on physical high-precision instruments is impractical due to high cost, safety risks, limited accessibility, and difficulty in ensuring reproducible evaluation. This motivates the need for a simulated yet realistic testbed that preserves the operational challenges of scientific instruments while enabling scalable and safe benchmarking. To this end, we introduce LabOSBench, a challenging benchmark for multimodal GUI agents built on a suite of web-based scientific-instrument simulators. Operating directly via a browser, LabOSBench avoids resource-heavy OS virtualization while supporting flexible task configuration and execution-based evaluation. Specifically, LabOSBench constructs 96 subtasks across eight instrument simulators, covering workflows from sample loading, alignment, parameter tuning, and data acquisition to result inspection. We evaluate general-purpose vision-language models, specialized GUI agent models, and advanced agentic frameworks at both subtask and end-to-end levels. Our experiments reveal that while existing agents can complete many structured GUI subtasks, they still struggle with feedback-driven operations and long-horizon workflow execution. Overall, LabOSBench provides a reproducible, low-cost testbed for advancing computer-using agents toward scientific-instrument control.