# To forget is to preserve: Machine Unlearning for 3D medical image segmentation

arXiv: https://arxiv.org/abs/2606.16180 · HTML: https://mlsanity.com/paper/2606.16180/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Machine unlearning, one of 12 directions in LLM safety and security.
- Builds on 26 of its 37 references that are in the map.
- First posted on arXiv 15 Jun 2026.

## Placed in

- LLM safety and security / [Machine unlearning](https://mlsanity.com/safety/machine-unlearning/)

## Builds on (most cited first, 26 of 26)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [Distilling the Knowledge in a Neural Network](https://mlsanity.com/paper/1503.02531/) (2015)
- [Overcoming catastrophic forgetting in neural networks](https://mlsanity.com/paper/1612.00796/) (2016)
- [V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentation](https://mlsanity.com/paper/1606.04797/) (2016)
- [Membership Inference Attacks against Machine Learning Models](https://mlsanity.com/paper/1610.05820/) (2016)
- [3D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotation](https://mlsanity.com/paper/1606.06650/) (2016)
- [A Survey on Deep Learning in Medical Image Analysis](https://mlsanity.com/paper/1702.05747/) (2017)
- [Machine Unlearning](https://mlsanity.com/paper/1912.03817/) (2019)
- [Multi-Task Learning as Multi-Objective Optimization](https://mlsanity.com/paper/1810.04650/) (2018)
- [Eternal Sunshine of the Spotless Net: Selective Forgetting in Deep Networks](https://mlsanity.com/paper/1911.04933/) (2019)
- [Making AI Forget You: Data Deletion in Machine Learning](https://mlsanity.com/paper/1907.05012/) (2019)
- [SalUn: Empowering Machine Unlearning via Gradient-based Weight Saliency in Both Image Classification and Generation](https://mlsanity.com/paper/2310.12508/) (2023)
- [Amnesiac Machine Learning](https://mlsanity.com/paper/2010.10981/) (2020)
- [A Survey of Machine Unlearning](https://mlsanity.com/paper/2209.02299/) (2022)
- [Med3D: Transfer Learning for 3D Medical Image Analysis](https://mlsanity.com/paper/1904.00625/) (2019)
- [Machine Unlearning of Features and Labels](https://mlsanity.com/paper/2108.11577/) (2021)
- [Fast Yet Effective Machine Unlearning](https://mlsanity.com/paper/2111.08947/) (2021)
- [Model Sparsity Can Simplify Machine Unlearning](https://mlsanity.com/paper/2304.04934/) (2023)
- [Deep Convolutional Neural Networks for Computer-Aided Detection: CNN Architectures, Dataset Characteristics and Transfer Learning](https://mlsanity.com/paper/1602.03409/) (2016)
- [Forgetting Outside the Box: Scrubbing Deep Networks of Information Accessible from Input-Output Observations](https://mlsanity.com/paper/2003.02960/) (2020)
- [The Right to be Forgotten in Federated Learning: An Efficient Realization with Rapid Retraining](https://mlsanity.com/paper/2203.07320/) (2022)
- [Recommendation Unlearning](https://mlsanity.com/paper/2201.06820/) (2022)
- [Machine Unlearning for Image-to-Image Generative Models](https://mlsanity.com/paper/2402.00351/) (2024)
- [Erase to Enhance: Data-Efficient Machine Unlearning in MRI Reconstruction](https://mlsanity.com/paper/2405.15517/) (2024)

## Abstract (arXiv)

With new data privacy laws such as the General Data Protection Regulation (GDPR) [1] that allow individuals to ask that any of their personal information be erased from trained machine learning models, there has been a push to investigate the unlearning of data from models as a way to comply with these laws. In this regard, based on four mechanics, we consider several approximate unlearning strategies applied to the MRBrainS18 dataset [2]. We use a 3D ResNet-50 [3] as a backbone architecture for segmentation that has been pre-trained with the Med3D framework [4]. Considering the pre-trained model as a baseline, we evaluate respective retention accuracy on 2 types of subjects, i.e., retain and forget. We assess these approaches through their Dice similarity coefficient and mean absolute error (MAE) values using two separate training horizons 20 and 50 epochs. The results show that the Noisy Label strategy had the best overall trade-off with a decrease of 93% in the forget set while maintaining 84% accuracy for the retained set after 50 epochs. All other strategies showed extreme levels of forgetting at higher epoch numbers while also demonstrating catastrophic degradation of their retain set performance. The results of this study provide a strict baseline of performance metrics for unlearning on a subject-specific level and provide practitioners with clear criteria for selecting the proper strategies.