# Mutual Distillation of Dual-Foundation Models for Semi-Supervised PET/CT Segmentation

arXiv: https://arxiv.org/abs/2606.15611 · HTML: https://mlsanity.com/paper/2606.15611/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 12 of its 17 references that are in the map.
- First posted on arXiv 14 Jun 2026.

## Builds on (most cited first, 12 of 12)

- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [Temporal Ensembling for Semi-Supervised Learning](https://mlsanity.com/paper/1610.02242/) (2016)
- [Semi-Supervised Semantic Segmentation with Cross Pseudo Supervision](https://mlsanity.com/paper/2106.01226/) (2021)
- [Uncertainty-aware Self-ensembling Model for Semi-supervised 3D Left Atrium Segmentation](https://mlsanity.com/paper/1907.07034/) (2019)
- [Label Propagation for Deep Semi-supervised Learning](https://mlsanity.com/paper/1904.04717/) (2019)
- [Shape-aware Semi-supervised 3D Semantic Segmentation for Medical Images](https://mlsanity.com/paper/2007.10732/) (2020)
- [SAM-Med3D: Towards General-purpose Segmentation Models for Volumetric Medical Images](https://mlsanity.com/paper/2310.15161/) (2023)
- [Learning with Limited Annotations: A Survey on Deep Semi-Supervised Learning for Medical Image Segmentation](https://mlsanity.com/paper/2207.14191/) (2022)
- [Scribble-Supervised Medical Image Segmentation via Dual-Branch Network and Dynamically Mixed Pseudo Labels Supervision](https://mlsanity.com/paper/2203.02106/) (2022)
- [SemiSAM: Enhancing Semi-Supervised Medical Image Segmentation via SAM-Assisted Consistency Regularization](https://mlsanity.com/paper/2312.06316/) (2023)
- [SegAnyPET: Universal Promptable Segmentation from Positron Emission Tomography Images](https://mlsanity.com/paper/2502.14351/) (2025)
- [Multi-modal Evidential Fusion Network for Trustworthy PET/CT Tumor Segmentation](https://mlsanity.com/paper/2406.18327/) (2024)

## Abstract (arXiv)

Organ segmentation from PET/CT is critical for quantitative analysis and radiotherapy planning in oncology. To ease the high annotation cost of PET/CT segmentation, semi-supervised learning (SSL) provides a practical and effective solution for developing deep models with limited labeled data. Recent developments in visual foundation models have demonstrated remarkable adaptability with improved efficiency. In this work, we propose a mutual distillation framework that seamlessly exploits both structural and functional foundation models, which act as modality-specific generalists for distilling knowledge from structural CT and metabolic PET imaging. By bridging the gap between the task-specific precision of student models and the segmentation priors of generalist foundation models, we propose MuDuo, a mutual distillation framework that synergistically leverages SAM-Med3D for CT and SegAnyPET for PET to distill their knowledge into a lightweight student network. Our approach eliminates the need for manual prompts while maximizing the utility of unlabeled data for automatic segmentation, achieving state-of-the-art performance on the AutoPET dataset with only 5 labeled cases. Our source code is available at https://github.com/Wu-beining/MuDuo.