# Toward Vibe Medicine: A Self-Evolving Multi-Agent Framework for Clinical Decision Support

arXiv: https://arxiv.org/abs/2606.15504 · HTML: https://mlsanity.com/paper/2606.15504/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical and scientific domain agents, one of 16 directions in LLM agents and tool use.
- Builds on 17 of its 29 references that are in the map.
- First posted on arXiv 1 Apr 2026.

## Placed in

- LLM agents and tool use / [Medical and scientific domain agents](https://mlsanity.com/agents/medical-and-scientific-domain-agents/)
- Synthetic data and self-improvement for LLMs / [Medical synthetic data and agents](https://mlsanity.com/synth/medical-synthetic-data-and-agents/)

## Builds on (most cited first, 17 of 17)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Retrieval-Augmented Generation for Knowledge-Intensive NLP Tasks](https://mlsanity.com/paper/2005.11401/) (2020)
- [Scaling Laws for Neural Language Models](https://mlsanity.com/paper/2001.08361/) (2020)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [A Survey on LLM-as-a-Judge](https://mlsanity.com/paper/2411.15594/) (2024)
- [Large Language Models for Software Engineering: A Systematic Literature Review](https://mlsanity.com/paper/2308.10620/) (2023)
- [Graph Retrieval-Augmented Generation: A Survey](https://mlsanity.com/paper/2408.08921/) (2024)
- [Continual Learning of Large Language Models: A Comprehensive Survey](https://mlsanity.com/paper/2404.16789/) (2024)
- [A Comprehensive Survey of Self-Evolving AI Agents: A New Paradigm Bridging Foundation Models and Lifelong Agentic Systems](https://mlsanity.com/paper/2508.07407/) (2025)
- [EvoScientist: Towards Multi-Agent Evolving AI Scientists for End-to-End Scientific Discovery](https://mlsanity.com/paper/2603.08127/) (2026)
- [The Ethics of ChatGPT in Medicine and Healthcare: A Systematic Review on Large Language Models (LLMs)](https://mlsanity.com/paper/2403.14473/) (2024)
- [Large Language Models for Medicine: A Survey](https://mlsanity.com/paper/2405.13055/) (2024)
- [Integration of Large Language Models and Federated Learning](https://mlsanity.com/paper/2307.08925/) (2023)
- [Automating Expert-Level Medical Reasoning Evaluation of Large Language Models](https://mlsanity.com/paper/2507.07988/) (2025)
- [MedBench: A Comprehensive, Standardized, and Reliable Benchmarking System for Evaluating Chinese Medical Large Language Models](https://mlsanity.com/paper/2407.10990/) (2024)
- [Vibe Coding as a Reconfiguration of Intent Mediation in Software Development: Definition, Implications, and Research Agenda](https://mlsanity.com/paper/2507.21928/) (2025)
- [MedBench v4: A Robust and Scalable Benchmark for Evaluating Chinese Medical Language Models, Multimodal Models, and Intelligent Agents](https://mlsanity.com/paper/2511.14439/) (2025)

## Abstract (arXiv)

In recent years, the advances of large language models and autonomous agents have revolutionized the healthcare field, facilitating diagnosis and improving treatment results. However, most existing AI systems rely on pre-trained knowledge and predefined pipelines, which struggle to learn dynamically from the interactive chat session history that contains patient outcomes and past failures. To address this limitation, we propose VIBEMed, a multi-agent framework with a built-in self-evolution mechanism and architecture-level safety sandbox for robust clinical decision support. The system integrates three specialized agents, including a Clinical Diagnostic Agent (CDA) for hypothesis generation, a Therapeutic Execution Agent (TEA) for treatment planning, and a Clinical Evolution Manager Agent (CEMA) that distills longitudinal clinical feedback into reusable knowledge, transforming multimodal patient information into personalized medical decisions. Through self-evolution mechanism, the framework enables iterative updates across memory, model behavior, and decision strategies, allowing the system to improve over time. Experimental results show that VIBEMed demonstrates superior performance through its evolving mechanism in complex clinical cases, particularly in tasks that require integrated decision-making and longitudinal planning. The framework also supports reliable end-to-end decisions in challenging scenarios such as oncology treatment planning, highlighting its feasibility in real-world clinical contexts. Overall, VIBEMed provides a practical path beyond static AI systems toward adaptive, experience-driven clinical decision support, demonstrating the value of combining multi-agent collaboration with continuous evolution for advancing precision medicine.