# Applicability Condition Extraction for Therapeutic Drug-Disease Relations

arXiv: https://arxiv.org/abs/2606.14031 · HTML: https://mlsanity.com/paper/2606.14031/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 17 of its 42 references that are in the map.
- First posted on arXiv 12 Jun 2026.

## Builds on (most cited first, 17 of 17)

- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [RoBERTa: A Robustly Optimized BERT Pretraining Approach](https://mlsanity.com/paper/1907.11692/) (2019)
- [BioBERT: a pre-trained biomedical language representation model for biomedical text mining](https://mlsanity.com/paper/1901.08746/) (2019)
- [Domain-Specific Language Model Pretraining for Biomedical Natural Language Processing](https://mlsanity.com/paper/2007.15779/) (2020)
- [Publicly Available Clinical BERT Embeddings](https://mlsanity.com/paper/1904.03323/) (2019)
- [BioRED: A Rich Biomedical Relation Extraction Dataset](https://mlsanity.com/paper/2204.04263/) (2022)
- [A Review of Biomedical Datasets Relating to Drug Discovery: A Knowledge Graph Perspective](https://mlsanity.com/paper/2102.10062/) (2021)
- [Instruction-Tuning LLMs for Event Extraction with Annotation Guidelines](https://mlsanity.com/paper/2502.16377/) (2025)
- [Infusing Hierarchical Guidance into Prompt Tuning: A Parameter-Efficient Framework for Multi-level Implicit Discourse Relation Recognition](https://mlsanity.com/paper/2402.15080/) (2024)
- [RST-LoRA: A Discourse-Aware Low-Rank Adaptation for Long Document Abstractive Summarization](https://mlsanity.com/paper/2405.00657/) (2024)
- [BioDEX: Large-Scale Biomedical Adverse Drug Event Extraction for Real-World Pharmacovigilance](https://mlsanity.com/paper/2305.13395/) (2023)
- [A Distant Supervision Corpus for Extracting Biomedical Relationships Between Chemicals, Diseases and Genes](https://mlsanity.com/paper/2204.06584/) (2022)
- [MEDVOC: Vocabulary Adaptation for Fine-tuning Pre-trained Language Models on Medical Text Summarization](https://mlsanity.com/paper/2405.04163/) (2024)
- [Supporting Medical Relation Extraction via Causality-Pruned Semantic Dependency Forest](https://mlsanity.com/paper/2208.13472/) (2022)
- [Convolutional neural networks for chemical-disease relation extraction are improved with character-based word embeddings](https://mlsanity.com/paper/1805.10586/) (2018)
- [Enhancing Adverse Drug Event Detection with Multimodal Dataset: Corpus Creation and Model Development](https://mlsanity.com/paper/2405.15766/) (2024)
- [Adverse Event Extraction from Discharge Summaries: A New Dataset, Annotation Scheme, and Initial Findings](https://mlsanity.com/paper/2506.14900/) (2025)

## Abstract (arXiv)

Identifying conditions that a certain drug takes therapeutic effect on a target disease is crucial for clinical decision-making support. However, most existing biomedical information extraction methods have focused on identifying only relations between drugs and diseases, while largely overlooking the context-specific conditions where such relations can apply. To address this problem, we introduce the task of applicability condition extraction for therapeutic drug-disease relations from biomedical research literature. We create the first dataset that has manually annotated triples of drugs, diseases, and applicability conditions on biomedical paper abstracts with 1,119 drug-disease pairs. Using this dataset, we systematically evaluate the performance of a range of existing methods. In addition, we propose a new method that enhances LoRA to consider relations between drugs and diseases. Our method consistently outperforms strong baselines across different evaluation settings.