# Less Is More: Training-Free Acceleration Framework of 3D Diffusion Models for Low-Count PET Denoising via Global-Local Trajectory Reduction

arXiv: https://arxiv.org/abs/2606.08751 · HTML: https://mlsanity.com/paper/2606.08751/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 11 of its 34 references that are in the map.
- First posted on arXiv 7 Jun 2026.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 11 of 11)

- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Wan: Open and Advanced Large-Scale Video Generative Models](https://mlsanity.com/paper/2503.20314/) (2025)
- [DPM-Solver: A Fast ODE Solver for Diffusion Probabilistic Model Sampling in Around 10 Steps](https://mlsanity.com/paper/2206.00927/) (2022)
- [FLUX.1 Kontext: Flow Matching for In-Context Image Generation and Editing in Latent Space](https://mlsanity.com/paper/2506.15742/) (2025)
- [Open-Sora: Democratizing Efficient Video Production for All](https://mlsanity.com/paper/2412.20404/) (2024)
- [Accelerating Diffusion Transformers with Token-wise Feature Caching](https://mlsanity.com/paper/2410.05317/) (2024)
- [FORA: Fast-Forward Caching in Diffusion Transformer Acceleration](https://mlsanity.com/paper/2407.01425/) (2024)
- [Progressive Distillation for Fast Sampling of Diffusion Models](https://mlsanity.com/paper/2202.00512/) (2022)
- [Training-Free Efficient Video Generation via Dynamic Token Carving](https://mlsanity.com/paper/2505.16864/) (2025)
- [SeaCache: Spectral-Evolution-Aware Cache for Accelerating Diffusion Models](https://mlsanity.com/paper/2602.18993/) (2026)

## Abstract (arXiv)

Accurate quantification and uptake measurement in PET are critical for assessing disease progression and supporting clinical decision-making. While high-count PET provides reliable image quality, the associated radiation dose and prolonged acquisition remain significant clinical concerns, motivating the adoption of low-count protocols. Diffusion-model-based methods have demonstrated strong potential for restoring low-count PET to near high-count quality, but their iterative sampling procedure becomes prohibitively expensive when applied to high-resolution 3D PET volumes, introducing substantial inference latency that limits practical clinical deployment. To address these challenges, we propose a training-free Global-Local Skipping Strategy that accelerates diffusion model-based 3D PET denoising while simultaneously improving reconstruction quality. The proposed method is plug-and-play and directly applicable to pre-trained diffusion models without retraining or architectural modification. Specifically, we introduce: (i) a global denoising step skipping strategy that initializes the reverse diffusion process from an intermediate denoising step using a noise-consistent transformation of the low-count input, substantially reducing the number of required denoising steps; and (ii) a local feature reuse shortcut that reuses slowly-varying high-level U-Net features across neighboring denoising steps, further reducing per-step computation while preserving image fidelity. We evaluate the proposed approach on multiple PET tracers from in-house and public datasets, including 18F-FDG PET, 68Ga-DOTATATE PET, and 18F-PSMA PET, demonstrating consistent acceleration of over an order of magnitude alongside improved or comparable reconstruction performance relative to the full-step baseline. Blinded reader studies further confirm enhanced clinical confidence and perceived diagnostic quality.