# CG-MambaNet: A spatiotemporal framework for cross-patient epileptic seizure prediction using CNN-GCN-Mamba-BiLSTM with event-level clinical evaluation

arXiv: https://arxiv.org/abs/2606.08226 · HTML: https://mlsanity.com/paper/2606.08226/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Physiological signal modeling, one of 10 directions in State-space sequence models (S4, Mamba).
- Builds on 9 of its 30 references that are in the map.
- First posted on arXiv 6 Jun 2026.

## Placed in

- State-space sequence models (S4, Mamba) / [Physiological signal modeling](https://mlsanity.com/ssm/physiological-signal-modeling/)

## Builds on (most cited first, 9 of 9)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Semi-Supervised Classification with Graph Convolutional Networks](https://mlsanity.com/paper/1609.02907/) (2016)
- [Graph Attention Networks](https://mlsanity.com/paper/1710.10903/) (2017)
- [Mamba: Linear-Time Sequence Modeling with Selective State Spaces](https://mlsanity.com/paper/2312.00752/) (2023)
- [Efficiently Modeling Long Sequences with Structured State Spaces](https://mlsanity.com/paper/2111.00396/) (2021)
- [EEGNet: A Compact Convolutional Network for EEG-based Brain-Computer Interfaces](https://mlsanity.com/paper/1611.08024/) (2016)
- [Deep learning-based electroencephalography analysis: a systematic review](https://mlsanity.com/paper/1901.05498/) (2019)
- [Machine Learning for Predicting Epileptic Seizures Using EEG Signals: A Review](https://mlsanity.com/paper/2002.01925/) (2020)
- [Focal onset seizure prediction using convolutional networks](https://mlsanity.com/paper/1805.11576/) (2018)

## Abstract (arXiv)

Epileptic seizure prediction from scalp EEG is critical for closed-loop neurostimulation therapy. Existing deep-learning methods share two architectural limitations: they model EEG channels independently, neglecting inter-channel spatial synchrony, and process raw time-domain samples without frequency decomposition. A methodological limitation also affects the field: most studies use data splits that permit patient-level information leakage, yielding optimistic estimates that do not generalise to unseen patients. We present CG-MambaNet, a spatiotemporal seizure prediction framework addressing all three limitations. A depthwise separable CNN front-end decomposes each EEG patch into multi-scale spectro-temporal features, capturing delta-to-gamma band dynamics before sequence modelling. A two-layer graph convolutional network with a learnable adjacency matrix captures inter-channel functional synchrony without montage-specific coordinates, applicable to bipolar (CHB-MIT) and referential (SIENA) montages. A bidirectional Mamba encoder followed by a bidirectional LSTM models long- and short-range temporal dynamics, and a two-layer MLP produces the final seizure probability. This serial hierarchy ensures frequency decomposition precedes spatial mixing, which precedes temporal integration. Under strict leave-one-patient-out cross-validation with five independent random seeds, CG-MambaNet achieves AUC-ROC of 0.8152+/-0.0176 on CHB-MIT (n=22) and 0.7104+/-0.0261 on SIENA (n=6), surpassing all published cross-patient methods without domain adaptation. An event-level evaluation framework merging consecutive alarmed windows via a persistence filter reduces false predictions to 0.32 alarms/hour on CHB-MIT, demonstrating clinically meaningful alarm burden.