# AMN: An Adaptive Multi-Scale Fusion Network with Boundary and Uncertainty Modeling for Nuclei Segmentation

arXiv: https://arxiv.org/abs/2606.07633 · HTML: https://mlsanity.com/paper/2606.07633/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 12 of its 33 references that are in the map.
- First posted on arXiv 31 May 2026.

## Builds on (most cited first, 12 of 12)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [Feature Pyramid Networks for Object Detection](https://mlsanity.com/paper/1612.03144/) (2016)
- [Encoder-Decoder with Atrous Separable Convolution for Semantic Image Segmentation](https://mlsanity.com/paper/1802.02611/) (2018)
- [SegNet: A Deep Convolutional Encoder-Decoder Architecture for Image Segmentation](https://mlsanity.com/paper/1511.00561/) (2015)
- [HoVer-Net: Simultaneous Segmentation and Classification of Nuclei in Multi-Tissue Histology Images](https://mlsanity.com/paper/1812.06499/) (2018)
- [From CNN to Transformer: A Review of Medical Image Segmentation Models](https://mlsanity.com/paper/2308.05305/) (2023)
- [BEFUnet: A Hybrid CNN-Transformer Architecture for Precise Medical Image Segmentation](https://mlsanity.com/paper/2402.08793/) (2024)
- [ConvFormer: Plug-and-Play CNN-Style Transformers for Improving Medical Image Segmentation](https://mlsanity.com/paper/2309.05674/) (2023)
- [Skin Lesion Segmentation Using Atrous Convolution via DeepLab v3](https://mlsanity.com/paper/1807.08891/) (2018)

## Abstract (arXiv)

Accurate classification of nuclei subtypes in histopathology images is critical for downstream tasks including tumor grading, immune infiltrate quantification, and prognosis prediction. Existing approaches rely on either convolutional or transformer-based encoders in isolation, limiting their ability to simultaneously capture fine-grained local texture and long-range spatial context. We present AMN (Adaptive Multi-Scale Nuclei Network), a dual-encoder segmentation framework that jointly leverages a Swin Transformer and a ResNet-50 feature pyramid, fused via a learned per-channel gating mechanism that dynamically weighs each encoder's contribution at every scale. AMN is trained with a multi-objective loss combining class-weighted focal loss, boundary-aware loss with positive-pixel emphasis, and a novel uncertainty-modulated classification term that suppresses overconfident erroneous predictions. Evaluated on the CoNIC benchmark across seven nuclei classes, AMN achieves a mean Dice of 0.82 and mean F1 of 0.68, with an F1 of 0.67 on the diagnostically challenging lymphocyte class. AMN outperforms eight baseline models spanning pure-CNN, pure-transformer, and recent hybrid architectures: U-Net, ResU-Net, DeepLabV3+, SegNet, ViT-Small, HmsU-Net, ConvFormer-UNet, and BEFUnet. Cross-dataset evaluation on MoNuSeg demonstrates strong generalization without retraining and validating the domain robustness of the learned representations.