# GlucoFM-Bench: Benchmarking Time-Series Foundation Models for Blood Glucose Forecasting

arXiv: https://arxiv.org/abs/2606.06881 · HTML: https://mlsanity.com/paper/2606.06881/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 20 of its 63 references that are in the map.
- First posted on arXiv 5 Jun 2026.

## Builds on (most cited first, 20 of 20)

- [Chronos: Learning the Language of Time Series](https://mlsanity.com/paper/2403.07815/) (2024)
- [Time-LLM: Time Series Forecasting by Reprogramming Large Language Models](https://mlsanity.com/paper/2310.01728/) (2023)
- [A decoder-only foundation model for time-series forecasting](https://mlsanity.com/paper/2310.10688/) (2023)
- [One Fits All:Power General Time Series Analysis by Pretrained LM](https://mlsanity.com/paper/2302.11939/) (2023)
- [Unified Training of Universal Time Series Forecasting Transformers](https://mlsanity.com/paper/2402.02592/) (2024)
- [Large Language Models Are Zero-Shot Time Series Forecasters](https://mlsanity.com/paper/2310.07820/) (2023)
- [Time-MoE: Billion-Scale Time Series Foundation Models with Mixture of Experts](https://mlsanity.com/paper/2409.16040/) (2024)
- [Foundation Models for Time Series Analysis: A Tutorial and Survey](https://mlsanity.com/paper/2403.14735/) (2024)
- [Timer: Generative Pre-trained Transformers Are Large Time Series Models](https://mlsanity.com/paper/2402.02368/) (2024)
- [UniTime: A Language-Empowered Unified Model for Cross-Domain Time Series Forecasting](https://mlsanity.com/paper/2310.09751/) (2023)
- [CALF: Aligning LLMs for Time Series Forecasting via Cross-modal Fine-Tuning](https://mlsanity.com/paper/2403.07300/) (2024)
- [Moirai 2.0: When Less Is More for Time Series Forecasting](https://mlsanity.com/paper/2511.11698/) (2025)
- [TSFM-Bench: A Comprehensive and Unified Benchmark of Foundation Models for Time Series Forecasting](https://mlsanity.com/paper/2410.11802/) (2024)
- [Output Scaling: YingLong-Delayed Chain of Thought in a Large Pretrained Time Series Forecasting Model](https://mlsanity.com/paper/2506.11029/) (2025)
- [Low-Rank Adaptation of Time Series Foundational Models for Out-of-Domain Modality Forecasting](https://mlsanity.com/paper/2405.10216/) (2024)
- [DiaTrend: A dataset from advanced diabetes technology to enable development of novel analytic solutions](https://mlsanity.com/paper/2304.06506/) (2023)
- [A Large Sensor Foundation Model Pretrained on Continuous Glucose Monitor Data for Diabetes Management](https://mlsanity.com/paper/2412.09727/) (2024)
- [AZT1D: A Real-World Dataset for Type 1 Diabetes](https://mlsanity.com/paper/2506.14789/) (2025)
- [A Comparative Study of Transformer-Based Models for Multi-Horizon Blood Glucose Prediction](https://mlsanity.com/paper/2505.08821/) (2025)
- [BrisT1D Dataset: Young Adults with Type 1 Diabetes in the UK using Smartwatches](https://mlsanity.com/paper/2507.17757/) (2025)

## Abstract (arXiv)

Blood glucose forecasting models are foundational for modern diabetes management systems, as reliable short-term predictions can enable proactive interventions, support automated insulin delivery, and reduce the risk of hypo- and hyperglycemic events. From a modeling perspective, glucose forecasting poses unique challenges due to heterogeneous physiological dynamics across diabetes populations. Traditional machine learning and deep learning models have been extensively evaluated for glucose prediction, yet recent time-series foundation models (TSFMs) remain much less studied in this setting. To bridge this gap, we present GlucoFM-Bench, a comprehensive benchmark evaluating state-of-the-art TSFMs alongside supervised deep learning models for blood glucose forecasting. We assess eight representative architectures, including pre-trained TSFMs, time-series large language models, and task-specific deep learning models, across 15 publicly available diabetes-relevant datasets comprising 1,117 individuals with type 1 diabetes, type 2 diabetes, prediabetes, and no diabetes. Models are evaluated under zero-shot, few-shot, and full-shot protocols, with systematic variation in context length and prediction horizon. Across datasets, pre-trained TSFMs, especially Chronos-2 and TimesFM, show strong zero-shot and few-shot transfer, with the best zero-shot model performing within 5% of the best full-shot supervised model. Yet, when task-specific data are abundant, a lightweight LSTM remains strongest, outperforming TSFMs by 4--21% under full-shot training. Stratified analyses reveal persistent challenges in T1D cohorts and hypo-/hyperglycemic ranges, highlighting the need for evaluation beyond aggregate error metrics. Together, GlucoFM-Bench provides a standardized and reproducible foundation for evaluating, comparing, and improving foundation models for blood glucose forecasting.